Evidence map›Paper›PMID 37628572›Full record

ArticleGenes2023

Matthias Christen, Isabel Zdora, Michael Leschnik, Vidhya Jagannathan, Christina Puff, Enrice Hünerfauth, Holger A Volk, Wolfgang Baumgärtner, Tessa C Koch, Wencke Schäfer and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Integrative MRI and Genomics Analyses PrioritizeAnimals : an open access journal from MDPI · 2026
    Article
  3. Article
  4. Genes · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Matthias ChristenInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.ORCID 0000-0003-3275-5929
Isabel ZdoraDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Michael LeschnikDepartment for Companion Animals and Horses, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
Vidhya JagannathanInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Christina PuffDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0002-2592-6868
Enrice HünerfauthDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Holger A VolkDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0002-7312-638X
Wolfgang BaumgärtnerDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0001-8151-5644
Tessa C KochBundeswehr School of Dog Handling, 56766 Ulmen, Germany.
Wencke SchäferBundeswehr School of Dog Handling, 56766 Ulmen, Germany.
Miriam KleiterDepartment for Companion Animals and Horses, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
Tosso LeebInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.ORCID 0000-0003-0553-4880
University of Veterinary Medicine Hannover, Foundation · DEUniversity of Bern · CHUniversity of Veterinary Medicine Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several genetically distinct forms of cerebellar ataxia exist in Belgian shepherd dogs. We investigated a litter in which two puppies developed cerebellar ataxia. The clinical signs stabilized at around six weeks of age, but remained visible into adulthood. Combined linkage and homozygosity mapping delineated a 5.5 Mb critical interval. The comparison of whole-genome sequence data of one affected dog to 929 control genomes revealed a private homozygous ~4.8 kb deletion in the critical interval, Chr8:14,468,376_14,473,136del4761. The deletion comprises exon 35 of the

Indexed as

CanidaeCerebellar AtaxiaAnimalsAtaxiaBelgiumDogsGTPase-Activating ProteinsHumansNerve Tissue ProteinsGTPase-Activating ProteinsNerve Tissue ProteinsRALGAPA1 protein, humananimal modelCanis lupus familiariscerebellumGARNL1neurogeneticsneurologyprecision medicine

Identifiers

PMID37628572
PMCPMC10454311
OpenAlexW4385318457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.