Evidence map›Paper›PMID 37628569›Full record

ArticleGenes2023

Brain Targeted AAV1-GALC Gene Therapy Reduces Psychosine and Extends Lifespan in a Mouse Model of Krabbe Disease.

Aimee R Herdt, Hui Peng, Dennis W Dickson, Todd E Golde, Elizabeth A Eckman, Chris W Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. CRISPR-mediated correction ofAnnals of medicine and surgery (2012) · 2025
    Article
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  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Aimee R HerdtBiomedical Research Institute of New Jersey, Cedar Knolls, NJ 07927, USA.
Hui PengBiomedical Research Institute of New Jersey, Cedar Knolls, NJ 07927, USA.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-7189-7917
Todd E GoldeDepartment of Pharmacology and Chemical Biology, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-1867-7071
Elizabeth A EckmanBiomedical Research Institute of New Jersey, Cedar Knolls, NJ 07927, USA.ORCID 0000-0002-5391-4960
Chris W LeeBiomedical Research Institute of New Jersey, Cedar Knolls, NJ 07927, USA.ORCID 0000-0001-9068-5274
Urology Associates · USEmory University · USMayo Clinic in Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Krabbe disease (KD) is a progressive and devasting neurological disorder that leads to the toxic accumulation of psychosine in the white matter of the central nervous system (CNS). The condition is inherited via biallelic, loss-of-function mutations in the galactosylceramidase (

Indexed as

Leukodystrophy, Globoid CellWhite MatterAnimalsBody WeightGalactosylceramidaseHydrolasesLongevityMiceProsencephalonPsychosineGalactosylceramidaseHydrolasesPsychosineadeno-associated virus serotype 1galactosylceramidasegene therapyKrabbe diseasepsychosinetwitcher

Identifiers

PMID37628569
PMCPMC10454254
OpenAlexW4385281963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.