Evidence map›Paper›PMID 37627875›Full record

ReviewBioengineering (Basel, Switzerland)2023

Neural Plasticity Changes Induced by Motor Robotic Rehabilitation in Stroke Patients: The Contribution of Functional Neuroimaging.

Lilla Bonanno, Antonio Cannuli, Loris Pignolo, Silvia Marino, Angelo Quartarone, Rocco Salvatore Calabrò, Antonio Cerasa

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Robotic rehabilitation with the LokomatFrontiers in aging neuroscience · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The evolution of neuromodulation for chronic stroke: From neuroplasticity mechanisms to brain-computer interfaces.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lilla BonannoIRCCS Centro Neurolesi Bonino Pulejo, 98123 Messina, Italy.ORCID 0000-0002-0282-405X
Antonio CannuliIRCCS Centro Neurolesi Bonino Pulejo, 98123 Messina, Italy.
Loris PignoloS'Anna Institute, 88900 Crotone, Italy.ORCID 0000-0001-9706-0779
Silvia MarinoIRCCS Centro Neurolesi Bonino Pulejo, 98123 Messina, Italy.
Angelo QuartaroneIRCCS Centro Neurolesi Bonino Pulejo, 98123 Messina, Italy.
Rocco Salvatore CalabròIRCCS Centro Neurolesi Bonino Pulejo, 98123 Messina, Italy.ORCID 0000-0002-8566-3166
Antonio CerasaS'Anna Institute, 88900 Crotone, Italy.

Funding

United States Department of Defense N° W81XWH-19-1-0810
6 · The paper itself

Abstract

Robotic rehabilitation is one of the most advanced treatments helping people with stroke to faster recovery from motor deficits. The clinical impact of this type of treatment has been widely defined and established using clinical scales. The neurofunctional indicators of motor recovery following conventional rehabilitation treatments have already been identified by previous meta-analytic investigations. However, a clear definition of the neural correlates associated with robotic neurorehabilitation treatment has never been performed. This systematic review assesses the neurofunctional correlates (fMRI, fNIRS) of cutting-edge robotic therapies in enhancing motor recovery of stroke populations in accordance with PRISMA standards. A total of 7, of the initial yield of 150 articles, have been included in this review. Lessons from these studies suggest that neural plasticity within the ipsilateral primary motor cortex, the contralateral sensorimotor cortex, and the premotor cortices are more sensitive to compensation strategies reflecting upper and lower limbs' motor recovery despite the high heterogeneity in robotic devices, clinical status, and neuroimaging procedures. Unfortunately, the paucity of RCT studies prevents us from understanding the neurobiological differences induced by robotic devices with respect to traditional rehabilitation approaches. Despite this technology dating to the early 1990s, there is a need to translate more functional neuroimaging markers in clinical settings since they provide a unique opportunity to examine, in-depth, the brain plasticity changes induced by robotic rehabilitation.

Indexed as

fMRIfNIRSmotor recoveryrobotic neurorehabilitationstroke

Identifiers

PMID37627875
PMCPMC10451271

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.