Non-Contrasted CT Radiomics for SAH Prognosis Prediction.

Subarachnoid hemorrhage (SAH) denotes a serious type of hemorrhagic stroke that often leads to a poor prognosis and poses a significant socioeconomic burden. Timely assessment of the prognosis of SAH patients is of paramount clinical importance for medical decision making. Currently, clinical prognosis evaluation heavily relies on patients' clinical information, which suffers from limited accuracy. Non-contrast computed tomography (NCCT) is the primary diagnostic tool for SAH. Radiomics, an emerging technology, involves extracting quantitative radiomics features from medical images to serve as diagnostic markers. However, there is a scarcity of studies exploring the prognostic prediction of SAH using NCCT radiomics features. The objective of this study is to utilize machine learning (ML) algorithms that leverage NCCT radiomics features for the prognostic prediction of SAH. Retrospectively, we collected NCCT and clinical data of SAH patients treated at Beijing Hospital between May 2012 and November 2022. The modified Rankin Scale (mRS) was utilized to assess the prognosis of patients with SAH at the 3-month mark after the SAH event. Based on follow-up data, patients were classified into two groups: good outcome (mRS ≤ 2) and poor outcome (mRS > 2) groups. The region of interest in NCCT images was delineated using 3D Slicer software, and radiomic features were extracted. The most stable and significant radiomic features were identified using the intraclass correlation coefficient,