ArticleBioengineering (Basel, Switzerland)2023
Empirical Quantification of Optic Nerve Strain Due to Horizontal Duction.
Article in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- Ocular Translation Due to Gravitational Acceleration.Investigative ophthalmology & visual science · 2025Article
- Tensile properties of glaucomatous human sclera, optic nerve, and optic nerve sheath.Biomechanics and modeling in mechanobiology · 2024Article
- Postmortem Digital Image Correlation and Finite Element Modeling Demonstrate Posterior Scleral Deformations during Optic Nerve Adduction Tethering.Bioengineering (Basel, Switzerland) · 2024Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Magnetic resonance imaging (MRI) was used to measure in vivo local strains in the optic nerve (ON) associated with horizontal duction in humans. Axial and coronal MRI were collected in target-controlled gazes in 24 eyes of 12 normal adults (six males and six females, 59 ± 16 years) during large (~28°) and moderate (~24°) ductions. The ON, globe, and extraocular muscles were manually identified, and the pixels were converted to point-sets that were registered across different imaging planes and eye positions. Shape of the ON was parameterized based on point-sets. Displacements and strains were computed by comparing deformed with initial ON configurations. Displacements were the largest in the most anterior region. However, strains from adduction were uniform along the length of the ON, while those during abduction increased with distance from the globe and were maximal near the orbital apex. For large gaze angles, ON strain during abduction was primarily due to bending near the orbital apex that is less transmitted to the eye, but during adduction the ON undergoes uniform stretching that transmits much greater loading to the posterior eye, implied by greater strain on the ON.
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Registered trials
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