Structure-Activity Relationships of Cationic Lipidoids against

James Jennings, Dunja Ašćerić, Nermina Malanovic, Georg Pabst

Abstract read

In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Combinatorial Screening of Cationic Lipidoids Reveals How Molecular Conformation Affects Membrane-Targeting Antimicrobial Activity.ACS applied materials & interfaces · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

James JenningsInstitute of Molecular Biosciences, University of Graz, NAWI Graz, 8010 Graz, Austria.

Dunja AšćerićInstitute of Molecular Biosciences, University of Graz, NAWI Graz, 8010 Graz, Austria.

Nermina MalanovicInstitute of Molecular Biosciences, University of Graz, NAWI Graz, 8010 Graz, Austria.ORCID 0000-0002-2903-9369

Georg PabstInstitute of Molecular Biosciences, University of Graz, NAWI Graz, 8010 Graz, Austria.ORCID 0000-0003-1967-1536

Funding

European Commission 893456

6 · The paper itself

Abstract

Membrane-active molecules provide a promising strategy to target and kill pathogenic bacteria. Understanding how specific molecular features drive interactions with membrane components and subsequently cause disruption that leads to antimicrobial activity is a crucial step in designing next-generation treatments. Here, we test a library of lipid-like compounds (lipidoids) against Gram-negative bacteria

Indexed as

combinatorial screeninglipidoidmembrane permeabilization

Identifiers

PMID37627720

DOI10.3390/antibiotics12081300

PMCPMC10451255

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.