Evidence map›Paper›PMID 37627327›Full record

ReviewBiomolecules2023

Oxidative Stress in Healthy and Pathological Red Blood Cells.

Florencia Orrico, Sandrine Laurance, Ana C Lopez, Sophie D Lefevre, Leonor Thomson, Matias N Möller, Mariano A Ostuni

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 2 pooled it
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Flavonoids: Hemorheological effects and mechanisms of action.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
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  7. Curcumin's Protective Effects Against HMolecules (Basel, Switzerland) · 2026
    Review
  8. Article
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  10. Redox Modulation of Erythropoiesis by Selenoproteins.Biological trace element research · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Main events and mechanism of human erythrocyte ageing.Expert reviews in molecular medicine · 2026
    Review
  18. Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Florencia OrricoLaboratorio de Fisicoquímica Biológica, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay.
Sandrine LauranceUniversité Paris Cité and Université des Antilles, UMR_S1134, BIGR, Inserm, F-75014 Paris, France.ORCID 0000-0002-2595-7031
Ana C LopezLaboratorio de Fisicoquímica Biológica, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay.
Sophie D LefevreUniversité Paris Cité and Université des Antilles, UMR_S1134, BIGR, Inserm, F-75014 Paris, France.ORCID 0000-0002-7504-1881
Leonor ThomsonLaboratorio de Enzimología, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay.
Matias N MöllerLaboratorio de Fisicoquímica Biológica, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay.
Mariano A OstuniUniversité Paris Cité and Université des Antilles, UMR_S1134, BIGR, Inserm, F-75014 Paris, France.ORCID 0000-0001-6769-3786
Universidad de la República de Uruguay · UYInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that affect the structure, function, or production of red blood cells (RBCs). These disorders can lead to various clinical manifestations, including anemia, hemolysis, inflammation, and impaired oxygen-carrying capacity. Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense mechanisms, plays a significant role in the pathophysiology of red cell diseases. In this review, we discuss the most relevant oxidant species involved in RBC damage, the enzymatic and low molecular weight antioxidant systems that protect RBCs against oxidative injury, and finally, the role of oxidative stress in different red cell diseases, including sickle cell disease, glucose 6-phosphate dehydrogenase deficiency, and pyruvate kinase deficiency, highlighting the underlying mechanisms leading to pathological RBC phenotypes.

Indexed as

Anemia, Hemolytic, Congenital NonspherocyticAnemia, Sickle CellAntioxidantsErythrocytesHumansOxidative StressAntioxidantsantioxidanterythrocyteglucose 6-phosphate dehydrogenase deficiencyoxidative stresspyruvate kinase deficiencyreactive oxygen speciessickle cell disease

Identifiers

PMID37627327
PMCPMC10452114
OpenAlexW4385986677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.