Evidence map›Paper›PMID 37627270›Full record

ArticleBiomolecules2023

Deleterious Interaction between the Neurosteroid (3α,5α)3-Hydroxypregnan-20-One (3α,5α-THP) and the Mu-Opioid System Activation during Forced Swim Stress in Rats.

Giorgia Boero, Minna H McFarland, Ryan E Tyler, Todd K O'Buckley, Samantha L Chéry, Donita L Robinson, Joyce Besheer, A Leslie Morrow

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Exercise as a mediator of wellbeing.Frontiers in psychology · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Giorgia BoeroBowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 3027 Thurston Bowles Bldg., CB 7178, Chapel Hill, NC 27599, USA.ORCID 0000-0001-7328-3943
Minna H McFarlandBowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 3027 Thurston Bowles Bldg., CB 7178, Chapel Hill, NC 27599, USA.
Ryan E TylerBowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 3027 Thurston Bowles Bldg., CB 7178, Chapel Hill, NC 27599, USA.
Todd K O'BuckleyBowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 3027 Thurston Bowles Bldg., CB 7178, Chapel Hill, NC 27599, USA.ORCID 0000-0001-8723-734X
Samantha L ChéryBowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 3027 Thurston Bowles Bldg., CB 7178, Chapel Hill, NC 27599, USA.
Donita L RobinsonBowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 3027 Thurston Bowles Bldg., CB 7178, Chapel Hill, NC 27599, USA.ORCID 0000-0001-7540-3363
Joyce BesheerBowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 3027 Thurston Bowles Bldg., CB 7178, Chapel Hill, NC 27599, USA.
A Leslie MorrowBowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 3027 Thurston Bowles Bldg., CB 7178, Chapel Hill, NC 27599, USA.
University of North Carolina at Chapel Hill · US

Funding

Gene Delivery of Neuroactive Steroids to Modulate Ethanol Reinforcement/ConsumptionR01AA024095 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BESHEER, JOYCE, MORROW, A LESLIE · 2017 to 2021
$2.0M
Allopregnanolone regulation of phasic dopamine release and motivated behaviorF31DA054781 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCFARLAND, MINNA HIKARU · 2021 to 2023
$115k
NIAAA NIH HHS R01 AA024095NIDA NIH HHS F31 DA054781
6 · The paper itself

Abstract

The neurosteroid 3α,5α-THP is a potent GABA

Indexed as

Analgesics, OpioidNeurosteroidsAnimalsFemaleHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemPregnanoloneRatsReceptors, GABA-ASwimmingAnalgesics, OpioidNeurosteroidsPregnanoloneReceptors, GABA-A3α,5α-THPallopregnanolonebehaviorbrexanoloneCTAPforced swim stressmu-opioid receptorneurosteroidsopioid systemstress

Identifiers

PMID37627270
PMCPMC10452864
OpenAlexW4385445146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.