Evidence map›Paper›PMID 37627260›Full record

ReviewBiomolecules2023

The Role of Poly(ADP-ribose) Polymerase 1 in Nuclear and Mitochondrial Base Excision Repair.

Geoffrey K Herrmann, Y Whitney Yin

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Mitochondrial DNA Damage and Its Repair Mechanisms in Aging Oocytes.International journal of molecular sciences · 2024
    Review
  8. Review
  9. Emerging treatment approaches for triple-negative breast cancer.Medical oncology (Northwood, London, England) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Geoffrey K HerrmannDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-0581-616X
Y Whitney YinDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
The University of Texas Medical Branch at Galveston · US

Funding

Structural Basis for Antiviral Drug Mitochondrial ToxicityR01AI134611 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI YIN, YUHUI · 2018 to 2022
$2.0M
Mitochondrial translesion DNA synthesisR01GM145925 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Yuhui Whitney Yin · 2023 to 2026
$1.4M
NIAID NIH HHS R01 AI134611NIGMS NIH HHS R01 GM145925
6 · The paper itself

Abstract

Poly(ADP-ribose) (PAR) Polymerase 1 (PARP-1), also known as ADP-ribosyl transferase with diphtheria toxin homology 1 (ARTD-1), is a critical player in DNA damage repair, during which it catalyzes the ADP ribosylation of self and target enzymes. While the nuclear localization of PARP-1 has been well established, recent studies also suggest its mitochondrial localization. In this review, we summarize the differences between mitochondrial and nuclear Base Excision Repair (BER) pathways, the involvement of PARP-1 in mitochondrial and nuclear BER, and its functional interplay with other BER enzymes.

Indexed as

DNA RepairPoly(ADP-ribose) Polymerase InhibitorsMitochondriaPoly Adenosine Diphosphate RibosePoly Adenosine Diphosphate RibosePoly(ADP-ribose) Polymerase InhibitorsDNA repairnuclear and mitochondrial localizationPARP-1

Identifiers

PMID37627260
PMCPMC10452840
OpenAlexW4385415852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.