Evidence map›Paper›PMID 37627092›Full record

ArticleCancers2023

BRD4 Inhibition as a Strategy to Prolong the Response to Standard of Care in Estrogen Receptor-Positive Breast Cancer.

Ahmed M Elshazly, Melanie M Sinanian, Victoria Neely, Eesha Chakraborty, Muruj A Alshehri, Michael K McGrath, Hisashi Harada, Patricia V Schoenlein, David A Gewirtz

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Evidence for cytoprotective autophagy in response to HER2-targeted monoclonal antibodies.The Journal of pharmacology and experimental therapeutics · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. The Cytoprotective Role of Autophagy in Response to BRAF-Targeted Therapies.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Ahmed M ElshazlyDepartments of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.ORCID 0000-0003-0353-1643
Melanie M SinanianDepartments of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Victoria NeelyMassey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Eesha ChakrabortyMassey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Muruj A AlshehriDepartments of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Michael K McGrathDepartment of Cellular Biology and Anatomy, MCG Cancer Center, Augusta University, Augusta, GA 30912, USA.
Hisashi HaradaMassey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.ORCID 0000-0001-5993-1289
Patricia V SchoenleinDepartment of Cellular Biology and Anatomy, MCG Cancer Center, Augusta University, Augusta, GA 30912, USA.
David A GewirtzDepartments of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.ORCID 0000-0003-0437-4934
Virginia Commonwealth University · USAugusta University Health · USKafrelsheikh University · EG

Funding

A sequential therapeutic strategy of senescence induction and senolytics for elimination of surviving residual breast tumor cellsR01CA260819 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI GEWIRTZ, DAVID A., HARADA, HISASHI · 2021 to 2025
$2.6M
6 · The paper itself

Abstract

Breast cancer is the most commonly occurring malignancy in women and the second most common cause of cancer-related deaths. ER

Indexed as

ABBV-744ARV-825BRD4c-Mycp53senescence

Identifiers

PMID37627092
PMCPMC10452571
OpenAlexW4385759911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.