ArticleCancers2023
Gallbladder Cancer Risk and Indigenous South American Mapuche Ancestry: Instrumental Variable Analysis Using Ancestry-Informative Markers.
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Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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19 citing papers in PubMed, 23 citations in OpenAlex.
- The Circulating Cholangiocarcinoma Protein Biomarkers CRP and MASP2 Also Predict Gallbladder Cancer Risk.International journal of cancer · 2026Article
- National Coordinated Care and Translational Research Program for Uveal Melanoma Pilot: Infrastructure, Biobanking, and Challenges in Liquid Biopsy Implementation in a Latin American Country.Ocular oncology and pathology · 2026Article
- Improving Gallbladder Cancer Outcomes with Antibody-Based Therapies and Immunological Profiling: A Literature Review.Antibodies (Basel, Switzerland) · 2026Review
- Geographic and genetic diversity in gallbladder cancer mutation profiles: insights from a worldwide exome analysis.EBioMedicine · 2026Article
- Persistently Higher Ratio of Gallbladder Cancer Incidence in Native American People than in Non-Hispanic Whites: Selected United States Regions, 1962-2021.Journal of racial and ethnic health disparities · 2026Article
- Stimulation of Skin Pigmentation with UVR Is a Risk Factor for Cholelithiasis.JID innovations : skin science from molecules to population health · 2025Review
- Genetic ancestry influences body shape and obesity risk in Latin American populations.Scientific reports · 2025Article
- Decreased Endothelin-1 bioavailability impairs aggressiveness of gallbladder cancer cells.Biological research · 2025Article
- Research and data sovereignty in genetically admixed populations. Reply to Zoller L, Kumar R and Lorenzo Bermejo J [letter].Diabetologia · 2025Article
- Research and data sovereignty in genetically admixed populations.Diabetologia · 2025Article
- International collaborative research to improve gallbladder cancer prevention.Nature reviews. Gastroenterology & hepatology · 2025Article
- Global variations in gallbladder cancer incidence: What do recorded data and national estimates tell us?International journal of cancer · 2025Article
- The mutational landscape and actionable targets of gallbladder cancer: an ancestry-informed and comparative analysis of a Chilean population.Frontiers in oncology · 2025Article
- Article
- Review
- Scientists and scientific journals should adhere to ethical standards for the use and reporting of data from Indigenous people.Diabetologia · 2024Article
- Clinical and Genomic Characterization ofJCO global oncology · 2024Article
- Distinct Driver Pathway Enrichments and a High Prevalence ofInternational journal of molecular sciences · 2024Article
- Targeting the Endothelin-1 pathway to reduce invasion and chemoresistance in gallbladder cancer cells.Cancer cell international · 2023Article
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Authors and funding
44 authors at 20 institutions in 11 countries.
Linda ZollnerStatistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.
Felix BoekstegersStatistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0002-0587-7624
Carol Barahona PonceStatistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0001-9505-4965
Dominique SchererStatistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0003-4430-296X
Katherine MarcelainDepartment of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago 8380000, Chile.ORCID 0000-0003-4018-6623
Valentina Gárate-CalderónStatistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.
Melanie WaldenbergerResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0003-0583-5093
Erik MoralesHospital Regional de Talca, Talca 3460000, Chile.ORCID 0000-0002-0271-2787
Armando RojasFacultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile.ORCID 0000-0001-9911-7142
César MunozHospital Regional de Talca, Talca 3460000, Chile.
Javier RetamalesInstituto Nacional del Cáncer, Santiago 7500650, Chile.ORCID 0000-0001-7051-0362
Gonzalo De ToroHospital de Puerto Montt, Puerto Montt 5480000, Chile.ORCID 0000-0003-1022-2865
Allan Vera KortmannHospital de Puerto Montt, Puerto Montt 5480000, Chile.
Olga BarajasDepartment of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago 8380000, Chile.
María Teresa RiveraHospital del Salvador, Santiago 7500922, Chile.
Analía CortésHospital del Salvador, Santiago 7500922, Chile.
Denisse LoaderHospital Padre Hurtado, Santiago 8880456, Chile.
Javiera SaavedraHospital Padre Hurtado, Santiago 8880456, Chile.
Lorena GutiérrezHospital San Juan de Dios, Santiago 8320000, Chile.
Alejandro OrtegaHospital Regional, Arica 1000000, Chile.
Maria Enriqueta BertránUnidad Registro Hospitalario de Cáncer, Hospital Base de Valdivia, Valdivia 5090146, Chile.
Leonardo BartolottiHospital Base de Valdivia, Valdivia 5090000, Chile.
Fernando GablerHospital San Borja Arriarán, Santiago 8320000, Chile.
Mónica CamposHospital San Borja Arriarán, Santiago 8320000, Chile.
Juan AlvaradoHospital Regional Guillermo Grant Benavente, Concepción 4070386, Chile.
Fabricio MoisánHospital Regional Guillermo Grant Benavente, Concepción 4070386, Chile.
Loreto SpencerHospital Regional Guillermo Grant Benavente, Concepción 4070386, Chile.ORCID 0000-0001-7728-015X
Bruno NerviDepartamento de Hematología y Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.ORCID 0000-0002-3016-7261
Daniel CarvajalFacultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7650568, Chile.ORCID 0000-0003-1742-729X
Héctor LosadaDepartamento de Cirugía, Universidad de la Frontera, Temuco 4780000, Chile.ORCID 0000-0002-8684-9675
Mauricio AlmauHospital de Rancagua, Rancagua 2820000, Chile.
Plinio FernándezHospital de Rancagua, Rancagua 2820000, Chile.
Jordi OlloquequiDepartment of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-6492-2739
Alice R CarterMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1UD, UK.
Juan Francisco Miquel PobleteDepartamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8320000, Chile.
Bernabe Ignacio BustosKen and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0003-2679-9503
Macarena Fuentes GuajardoDepartamento de Tecnología Médica, Facultad de Ciencias de la Salud, Tarapacá University, Arica 1000815, Chile.
Rolando Gonzalez-JoseInstituto Patagónico de Ciencias Sociales y Humanas, Centro Nacional Patagónico, CONICET, Puerto Madryn U9120ACD, Argentina.ORCID 0000-0002-8128-9381
Maria Cátira BortoliniInstituto de Biociências, Universidad Federal do Rio Grande do Sul, Puerto Alegre 15053, Brazil.ORCID 0000-0003-0598-3854
Victor Acuña-AlonzoNational Institute of Anthropology and History, Mexico City 06600, Mexico.
Carla GalloLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 15102, Peru.
Andres Ruiz LinaresMinistry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai 200434, China.
Francisco RothhammerInstituto de Alta Investigación, Tarapacá University, Arica 1000000, Chile.
Justo Lorenzo BermejoStatistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0002-6568-5333
Heidelberg University · DECatholic University of the Maule · CLHospital Regional de Concepción · CLHospital Base · CLHospital del Salvador · CLHospital Padre Hurtado · CLHospital Regional Rancagua · CLHospital San Borja Arriarán · CLPontificia Universidad Católica de Chile · CLUniversity of Tarapacá · CLAix-Marseille Université · FRAustral University of Chile · CLCentro Científico Tecnológico Patagónico · ARGerman Cancer Research Center · DEHelmholtz Zentrum München · DEHospital Clínico de la Universidad de Chile · CLHospital Regional de Arica Doctor Juan Noé Crevani · CLHospital San Juan de Dios · CLInstituto Nacional del Cáncer · CLNational Institute of Anthropology and History · MX
Funding
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–European Commission 825741NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237
Abstract
A strong association between the proportion of indigenous South American Mapuche ancestry and the risk of gallbladder cancer (GBC) has been reported in observational studies. Chileans show the highest incidence of GBC worldwide, and the Mapuche are the largest indigenous people in Chile. We set out to assess the confounding-free effect of the individual proportion of Mapuche ancestry on GBC risk and to investigate the mediating effects of gallstone disease and body mass index (BMI) on this association. Genetic markers of Mapuche ancestry were selected based on the informativeness for assignment measure, and then used as instrumental variables in two-sample Mendelian randomization analyses and complementary sensitivity analyses. Results suggested a putatively causal effect of Mapuche ancestry on GBC risk (inverse variance-weighted (IVW) risk increase of 0.8% per 1% increase in Mapuche ancestry proportion, 95% CI 0.4% to 1.2%,
Indexed as
ancestry-informative markerscausal inferencegallbladder cancergallstone diseasegenetic admixtureindigenous South American Mapuche ancestryinstrumental variablesMendelian randomization
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