Evidence map›Paper›PMID 37626917›Full record

ArticleCells2023

Emerging Role of Kinin B1 Receptor in Persistent Neuroinflammation and Neuropsychiatric Symptoms in Mice Following Recovery from SARS-CoV-2 Infection.

Srinivas Sriramula, Drew Theobald, Rohan Umesh Parekh, Shaw M Akula, Dorcas P O'Rourke, Jeffrey B Eells

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Inhibition of kinin B1 receptor alleviates SARS-CoV-2-induced long-lasting cardiovascular complications.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  6. Review
  7. Translating insights into therapies for Long Covid.Science translational medicine · 2024
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Srinivas SriramulaDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.ORCID 0000-0001-9937-1589
Drew TheobaldDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.ORCID 0000-0002-6534-0909
Rohan Umesh ParekhDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.ORCID 0000-0002-6552-795X
Shaw M AkulaDepartment of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Dorcas P O'RourkeDepartment of Comparative Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Jeffrey B EellsDepartment of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
East Carolina University · US

Funding

Neuroimmune Mechanisms of Kinin B1 Receptor in HypertensionR01HL153115 · NHLBI · EAST CAROLINA UNIVERSITY · PI SRIRAMULA, SRINIVAS · 2020 to 2024
$1.8M
Impact of Seasonal Variation in Hematocrit, NOx & ET-1 on Vascular ReactivityR21NR010361 · NINR · UNIVERSITY OF MISSOURI-COLUMBIA · PI WIPKE-TEVIS, DEIDRE D · 2008 to 2009
$401k
NHLBI NIH HHS R01 HL153115NINR NIH HHS R21 NR010361
6 · The paper itself

Abstract

Evidence suggests that patients with long COVID can experience neuropsychiatric, neurologic, and cognitive symptoms. However, these clinical data are mostly associational studies complicated by confounding variables, thus the mechanisms responsible for persistent symptoms are unknown. Here we establish an animal model of long-lasting effects on the brain by eliciting mild disease in K18-hACE2 mice. Male and female K18-hACE2 mice were infected with 4 × 10

Indexed as

COVID-19AnimalsFemalegamma-GlobulinsHumansKininsMaleMelphalanMiceNeuroinflammatory DiseasesPost-Acute COVID-19 SyndromeSARS-CoV-2gamma-GlobulinsK-18 conjugateKininsMelphalanCOVID-19K18-hACE2 micekinin B1 receptorlong COVIDneuroinflammationSARS-CoV-2

Identifiers

PMID37626917
PMCPMC10453171
OpenAlexW4386028831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.