Evidence map›Paper›PMID 37626903›Full record

ArticleCells2023

Skin-Grafting and Dendritic Cell "Boosted" Humanized Mouse Models Allow the Pre-Clinical Evaluation of Therapeutic Cancer Vaccines.

Bijun Zeng, Davide Moi, Lynn Tolley, Natalie Molotkov, Ian Hector Frazer, Christopher Perry, Riccardo Dolcetti, Roberta Mazzieri, Jazmina L G Cruz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bijun ZengPeter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Davide MoiPeter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Lynn TolleyFrazer Institute, The University of Queensland, Brisbane, QLD 4102, Australia.
Natalie MolotkovFrazer Institute, The University of Queensland, Brisbane, QLD 4102, Australia.
Ian Hector FrazerFrazer Institute, The University of Queensland, Brisbane, QLD 4102, Australia.ORCID 0000-0002-8002-4680
Christopher PerryFaculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.
Riccardo DolcettiPeter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.ORCID 0000-0003-1625-9853
Roberta MazzieriPeter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Jazmina L G CruzFrazer Institute, The University of Queensland, Brisbane, QLD 4102, Australia.ORCID 0000-0003-2671-7408
The University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccines have been hailed as one of the most remarkable medical advancements in human history, and their potential for treating cancer by generating or expanding anti-tumor T cells has garnered significant interest in recent years. However, the limited efficacy of therapeutic cancer vaccines in clinical trials can be partially attributed to the inadequacy of current preclinical mouse models in recapitulating the complexities of the human immune system. In this study, we developed two innovative humanized mouse models to assess the immunogenicity and therapeutic effectiveness of vaccines targeting human papillomavirus (HPV16) antigens and delivering tumor antigens to human CD141

Indexed as

Cancer VaccinesMelanomaAnimalsAntibodiesAntigens, NeoplasmDendritic CellsDisease Models, AnimalHLA-A AntigensHumansHyperplasiaLeukocytes, MononuclearMiceSkin TransplantationAntibodiesAntigens, NeoplasmCancer VaccinesHLA-A Antigensanimal modelsbreast cancercancerdendritic cellsHPVhumanized-mouse modelsmelanomaT cellsvaccine

Identifiers

PMID37626903
PMCPMC10453599
OpenAlexW4385987088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.