ArticleBiomedicines2023
Optimizing TMS Coil Placement Approaches for Targeting the Dorsolateral Prefrontal Cortex in Depressed Adolescents: An Electric Field Modeling Study.
Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- A Multisite, 6-Month, Open-Label Study of Maintenance Transcranial Magnetic Stimulation for Adolescents with Treatment-Resistant Depression.Journal of child and adolescent psychopharmacology · 2025Trial
- Trial
- Efficacy of Personalized Connectivity-Guided Accelerated Brain Stimulation in a Naturalistic Treatment-Resistant Depression Population.medRxiv : the preprint server for health sciences · 2026Article
- High dosage accelerated intermittent theta burst stimulation without precision targeting and dosing in depression: an open-label pilot study.European archives of psychiatry and clinical neuroscience · 2026Article
- Measuring transcranial magnetic stimulation-induced electric fields in anatomically and conductively accurate rat head phantoms.Journal of neural engineering · 2026Article
- Roadmap towards personalized approaches and safety considerations in non-ionizing radiation: from dosimetry to therapeutic and diagnostic applications.Physics in medicine and biology · 2026Review
- Physical Therapy for Treatment-Resistant Depression A Comprehensive Review of Efficacy, Safety, and Evidence Grading.Neuropsychiatric disease and treatment · 2026Review
- Neurodevelopmental considerations for transcranial magnetic stimulation trials in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- [Development and electrophysiological validation of a temporal interference transcranial magnetic stimulation system for mice].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- A naturalistic analysis of rTMS treatment outcomes for major depressive disorder in West Australian youth.Frontiers in psychiatry · 2025Article
- Novel Volume Integral Equation Approach for Low-Frequency E-Field Dosimetry of Transcranial Magnetic Stimulation.IEEE transactions on magnetics · 2024Article
- Multi-scale modeling to investigate the effects of transcranial magnetic stimulation on morphologically-realistic neuron with depression.Cognitive neurodynamics · 2024Article
- A semi-automated pipeline for finite element modeling of electric field induced in nonhuman primates by transcranial magnetic stimulation.Journal of neuroscience methods · 2024Article
- A New Angle on Transcranial Magnetic Stimulation Coil Orientation: A Targeted Narrative Review.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Review
- Electric Field Modeling in Personalizing Transcranial Magnetic Stimulation Interventions.Biological psychiatry · 2024Review
- Treatment-Resistant Depression in America Latina study: one-year follow-up of treatment resistant depression patients under standard of care reveals insights on quality of life, disability, work impairment, and depressive symptoms.Frontiers in psychiatry · 2023Article
- Template MRI scans reliably approximate individual and group-level tES and TMS electric fields induced in motor and prefrontal circuits.Frontiers in neural circuits · 2023Article
- Electric field distribution predicts efficacy of accelerated intermittent theta burst stimulation for late-life depression.Frontiers in psychiatry · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
High-frequency repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (L-DLPFC) shows promise as a treatment for treatment-resistant depression in adolescents. Conventional rTMS coil placement strategies include the 5 cm, the Beam F3, and the magnetic resonance imaging (MRI) neuronavigation methods. The purpose of this study was to use electric field (E-field) models to compare the three targeting approaches to a computational E-field optimization coil placement method in depressed adolescents. Ten depressed adolescents (4 females, age: 15.9±1.1) participated in an open-label rTMS treatment study and were offered MRI-guided rTMS five times per week over 6-8 weeks. Head models were generated based on individual MRI images, and E-fields were simulated for the four targeting approaches. Results showed a significant difference in the induced E-fields at the L-DLPFC between the four targeting methods (χ2=24.7, p<0.001). Post hoc pairwise comparisons showed that there was a significant difference between any two of the targeting methods (Holm adjusted p<0.05), with the 5 cm rule producing the weakest E-field (46.0±17.4V/m), followed by the F3 method (87.4±35.4V/m), followed by MRI-guided (112.1±14.6V/m), and followed by the computational approach (130.1±18.1V/m). Variance analysis showed that there was a significant difference in sample variance between the groups (K2=8.0, p<0.05), with F3 having the largest variance. Participants who completed the full course of treatment had median E-fields correlated with depression symptom improvement (r=-0.77, p<0.05). E-field models revealed limitations of scalp-based methods compared to MRI guidance, suggesting computational optimization could enhance dose delivery to the target.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.