Evidence map›Paper›PMID 37626562›Full record

ReviewBrain sciences2023

Pharmacological Treatment of Alcohol Cravings.

Matheus Cheibub David Marin, Maria Olívia Pozzolo Pedro, Giuliana Perrotte, Anderson S Martins-da-Silva, Dangela L S Lassi, Israel Kanaan Blaas, Fernando Ikeda Castaldelli, Maria Beatriz Brisola Dos Santos, Guilherme Trevizan Kortas, Marcela Waisman Campos and 8 more

Open access · goldAbstract readReview
In one paragraph

Review in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 4 countries.

Matheus Cheibub David MarinPerdizes Institute (IPer), Clinics Hospital of the Medical School (HCFMUSP), University of São Paulo, São Paulo 05021-001, Brazil.
Maria Olívia Pozzolo PedroHospital Sírio-Libanês, São Paulo 01308-050, Brazil.ORCID 0000-0003-1336-093X
Giuliana PerrotteDepartment of Neuroscience, Medical School, FMABC University Center, Santo André 09060-870, Brazil.
Anderson S Martins-da-SilvaDepartment of Psychiatry, Medical School, University of São Paulo, São Paulo 05403-903, Brazil.ORCID 0000-0001-9961-9337
Dangela L S LassiPerdizes Institute (IPer), Clinics Hospital of the Medical School (HCFMUSP), University of São Paulo, São Paulo 05021-001, Brazil.ORCID 0000-0002-7024-5623
Israel Kanaan BlaasPerdizes Institute (IPer), Clinics Hospital of the Medical School (HCFMUSP), University of São Paulo, São Paulo 05021-001, Brazil.
Fernando Ikeda CastaldelliMedical School Catanduva (FAMECA), Padre Albino University Center, Catanduva 15809-144, Brazil.
Maria Beatriz Brisola Dos SantosHospital Sírio-Libanês, São Paulo 01308-050, Brazil.
Guilherme Trevizan KortasPerdizes Institute (IPer), Clinics Hospital of the Medical School (HCFMUSP), University of São Paulo, São Paulo 05021-001, Brazil.ORCID 0000-0003-2447-5388
Marcela Waisman CamposDepartment of Cognitive Neurology, Neuropsychiatry, and Neuropsychology, Fleni, Buenos Aires C1428AQK, Argentina.ORCID 0000-0003-2728-7876
Julio ToralesDepartment of Medical Psychology, School of Medical Sciences, Universidad Nacional de Asunción, San Lorenzo 111454, Paraguay.ORCID 0000-0003-3277-7036
Antonio VentriglioDepartment of Experimental Medicine, Medical School, University of Foggia, 71100 Foggia, Italy.ORCID 0000-0002-3934-7007
Cintia de Azevedo-Marques PéricoDepartment of Neuroscience, Medical School, FMABC University Center, Santo André 09060-870, Brazil.ORCID 0000-0002-2664-5101
André B NegrãoPerdizes Institute (IPer), Clinics Hospital of the Medical School (HCFMUSP), University of São Paulo, São Paulo 05021-001, Brazil.
Kae LeopoldoDepartment of Psychiatry, Medical School, University of São Paulo, São Paulo 05403-903, Brazil.ORCID 0000-0002-5541-8397
Arthur Guerra de AndradePerdizes Institute (IPer), Clinics Hospital of the Medical School (HCFMUSP), University of São Paulo, São Paulo 05021-001, Brazil.
André MalbergierPerdizes Institute (IPer), Clinics Hospital of the Medical School (HCFMUSP), University of São Paulo, São Paulo 05021-001, Brazil.
João Maurício Castaldelli-MaiaHospital Sírio-Libanês, São Paulo 01308-050, Brazil.ORCID 0000-0001-9621-2291
Universidade de São Paulo · BRFaculdade de Medicina do ABC · BRFundação Padre Albino · BRHospital Sírio-Libanês · BRInstituto de Neurología Cognitiva · ARUniversidad Nacional De Caaguazú · PYUniversity of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: The treatment of substance addiction is challenging and has persisted for decades, with only a few therapeutic options. Although there are some recommendations for specific treatments for Alcohol Use Disorder (AUD), there is no specific medication used to treat alcohol cravings, which could benefit millions of patients that are suffering from alcoholism. Cravings, or the urge to use drugs, refer to the desire to experience the effects of a previously experienced psychoactive substance. (2) Methods: We included original studies of alcohol abuse or dependence extracted from a controlled, blind, pharmacological treatment study which presented measures and outcomes related to alcohol cravings. (3) Results: Specific drugs used for the treatment of alcoholism, such as Naltrexone and Acamprosate, have had the best results in relieving craving symptoms, as well as promoting abstinence. Baclofen and anticonvulsants such as Gabapentin and Topiramate have shown good results in promoting abstinence and the cessation of cravings. (4) Conclusions: Specific drugs used for the treatment of alcoholism to obtain the best results can be considered the gold standard for promoting abstinence and relieving cravings. Anticonvulsants and Baclofen also had good results, with these medications being considered as second-line ones. Varenicline is an option for alcohol dependents who also concomitantly ingest tobacco.

Indexed as

alcoholcravingrandomi* controlled blind*

Identifiers

PMID37626562
PMCPMC10452441
OpenAlexW4385840446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.