Evidence map›Paper›PMID 37626447›Full record

ReviewJapanese journal of clinical oncology2023

Advances in treatment of alveolar soft part sarcoma: an updated review.

Tomohiro Fujiwara, Toshiyuki Kunisada, Eiji Nakata, Kenji Nishida, Hiroyuki Yanai, Tomoki Nakamura, Kazuhiro Tanaka, Toshifumi Ozaki

Abstract readReview
In one paragraph

Review in Japanese journal of clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. How I treat soft tissue sarcomas.Future oncology (London, England) · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Alveolar Soft Part Sarcoma in a 44-year-Old Female: A Case from Uganda.International medical case reports journal · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. A framework for target discovery in rare cancers.bioRxiv : the preprint server for biology · 2024
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tomohiro FujiwaraDepartment of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.ORCID 0000-0003-4257-9180
Toshiyuki KunisadaDepartment of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.ORCID 0000-0002-1775-850X
Eiji NakataDepartment of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.ORCID 0000-0002-5971-4142
Kenji NishidaDepartment of Pathology, Okayama University Hospital, Okayama, Japan.
Hiroyuki YanaiDepartment of Pathology, Okayama University Hospital, Okayama, Japan.
Tomoki NakamuraDepartment of Orthopaedic Surgery, Mie University, Tsu, Japan.ORCID 0000-0002-1099-7436
Kazuhiro TanakaDepartment of Advanced Medical Sciences, Oita University, Yufu, Japan.ORCID 0000-0002-5138-8952
Toshifumi OzakiDepartment of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

Funding

Japan Society for the Promotion of Science 21K16709
6 · The paper itself

Abstract

Alveolar soft part sarcoma is a rare neoplasm of uncertain histogenesis that belongs to a newly defined category of ultra-rare sarcomas. The neoplasm is characterized by a specific chromosomal translocation, der (17) t(X; 17)(p11.2;q25), that results in ASPSCR1-TFE3 gene fusion. The natural history of alveolar soft part sarcoma describes indolent behaviour with slow progression in deep soft tissues of the extremities, trunk and head/neck in adolescents and young adults. A high rate of detection of distant metastasis at presentation has been reported, and the most common metastatic sites in decreasing order of frequency are the lung, bone and brain. Complete surgical resection remains the standard treatment strategy, whereas radiotherapy is indicated for patients with inadequate surgical margins or unresectable tumours. Although alveolar soft part sarcoma is refractory to conventional doxorubicin-based chemotherapy, monotherapy or combination therapy using tyrosine kinase inhibitors and immune checkpoint inhibitors have provided antitumor activity and emerged as new treatment strategies. This article provides an overview of the current understanding of this ultra-rare sarcoma and recent advancements in treatments according to the clinical stage of alveolar soft part sarcoma.

Indexed as

Sarcoma, Alveolar Soft PartSoft Tissue NeoplasmsAdolescentCombined Modality TherapyHumansOncogene Proteins, FusionTranslocation, GeneticYoung AdultOncogene Proteins, Fusionalveolar soft part sarcomachemotherapyimmunotherapysurgerytargeted therapy

Identifiers

PMID37626447
PMCPMC10632598

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.