Evidence map›Paper›PMID 37626428›Full record

ArticleTrials2023

Technology-assisted cognitive-behavior therapy delivered by peers versus standard cognitive behavior therapy delivered by community health workers for perinatal depression: study protocol of a cluster randomized controlled non-inferiority trial.

Atif Rahman, Abid Malik, Najia Atif, Huma Nazir, Ahmed Zaidi, Anum Nisar, Ahmed Waqas, Maria Sharif, Tao Chen, Duolao Wang and 1 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05353491 (Technology-assisted Cognitive-behaviour Therapy Delivered by Peers Versus Standard Cognitive Behaviour Therapy Delivered by Community Health Workers for Perinatal Depression), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05353491 nacompletednot on this map

Technology-assisted Cognitive-behaviour Therapy Delivered by Peers Versus Standard Cognitive Behaviour Therapy Delivered by Community Health Workers for Perinatal Depression: A Cluster Randomised Controlled Non-inferiority Trial

TypeinterventionalSponsorHuman Development Research Foundation, PakistanRan2022 to 2024Enrolled980ConditionsPerinatal Depression, Depression, PostpartumArmsTechnology assisted Thinking Healthy Program (THP-TA), Standard Thinking Healthy Program
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Atif RahmanDepartment of Primary Care and Mental Health, Institute of Population Health, University of Liverpool, Waterhouse Building, Block B First Floor, 1-5 Dover Street, Liverpool, L69 3GL, UK. atif.rahman@liverpool.ac.uk.ORCID http://orcid.org/0000-0002-2066-4467
Abid MalikHealth Services Academy, Islamabad, Pakistan.
Najia AtifHuman Development Research Foundation, Islamabad, Pakistan.
Huma NazirHuman Development Research Foundation, Islamabad, Pakistan.
Ahmed ZaidiHuman Development Research Foundation, Islamabad, Pakistan.
Anum NisarHuman Development Research Foundation, Islamabad, Pakistan.
Ahmed WaqasDepartment of Primary Care and Mental Health, Institute of Population Health, University of Liverpool, Waterhouse Building, Block B First Floor, 1-5 Dover Street, Liverpool, L69 3GL, UK.
Maria SharifHuman Development Research Foundation, Islamabad, Pakistan.
Tao ChenUniversity of York, York, UK.
Duolao WangLiverpool School of Tropical Medicine, Liverpool, UK.
Siham SikanderDepartment of Primary Care and Mental Health, Institute of Population Health, University of Liverpool, Waterhouse Building, Block B First Floor, 1-5 Dover Street, Liverpool, L69 3GL, UK.
Human Development Research Foundation · PKUniversity of Liverpool · GBHealth Services Academy · PKLiverpool School of Tropical Medicine · GBUniversity of York · GB

Funding

National Institute for Health and Care Research NIHR200817
6 · The paper itself

Abstract

backgroundThe lack of trained mental health professionals is a key barrier to scale-up of evidence-based psychological interventions in low and middle-income countries. We have developed an app that allows a peer with no prior experience of health-care delivery to deliver the cognitive therapy-based intervention for perinatal depression, the Thinking Healthy Programme (THP). This trial aims to assess the effectiveness and cost-effectiveness of this Technology-assisted peer-delivered THP versus standard face-to-face Thinking Healthy Programme delivered by trained health workers.

methodsWe will employ a non-inferiority stratified cluster randomized controlled trial design comparing the two formats of intervention delivery. A total of 980 women in the second or third trimester of pregnancy with a diagnosis of Major Depressive Episode, evaluated with the Structured Clinical Interview for DSM-V Disorders (SCID), will be recruited into the trial. The unit of randomization will be 70 village clusters randomly allocated in a 1:1 ratio to the intervention and control arms. The primary outcome is defined as remission from major depressive episode at 3 months postnatal measured with the SCID. Data will also be collected on symptoms of anxiety, disability, quality of life, service use and costs, and infant-related outcomes such as exclusive breastfeeding and immunization rates. Data will be collected on the primary outcome and selected secondary outcomes (depression and anxiety scores, exclusive breastfeeding) at 6 months postnatal to evaluate if the improvements are sustained in the longer-term. We are especially interested in sustained improvement (recovery) from major depressive episode. DISCUSSION: This trial will evaluate the effectiveness and cost-effectiveness of a technology-assisted peer-delivered cognitive behavioral therapy-based intervention in rural Pakistan. If shown to be effective, the novel delivery format could play a role in reducing the treatment gap for perinatal depression and other common mental disorders in LMIC.

trial registrationThe trial was registered at Clinicaltrials.gov (NCT05353491) on 29 April 2022.

Indexed as

Cognitive Behavioral TherapyMajor Depressive DisorderCommunity Health WorkersEquivalence Trials as TopicFemaleHumansPregnancyQuality of LifeRandomized Controlled Trials as TopicCognitive-behavioral therapyDigital interventionMental healthPerinatal depressionPsychosocial interventionTechnologyThinking Healthy Programme

Identifiers

PMID37626428
PMCPMC10463295
OpenAlexW4386167455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.