Evidence map›Paper›PMID 37626269›Full record

ArticleMolecular neurobiology2024

Phytochemical Extract from Carica papaya Leaves and Punica granatum Seeds as Therapy Against Cognitive Impairment in a Murine Model.

Cristian Gonzalez-Ruiz, Miguel Ortiz-Flores, Jorge Bernal-Hernández, Rodrigo Mondragon-Lozano, Alam Palma-Guzman, Angélica Coyoy-Salgado, Hermelinda Salgado-Ceballos

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Cristian Gonzalez-RuizFacultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Estado de Mexico, Mexico.ORCID http://orcid.org/0000-0003-0140-291X
Miguel Ortiz-FloresEscuela Superior de Medicina, Instituto Politécnico Nacional, Miguel Hidalgo, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-6091-2448
Jorge Bernal-HernándezFacultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Estado de Mexico, Mexico.ORCID http://orcid.org/0000-0002-8989-3639
Rodrigo Mondragon-LozanoResearchers for Mexico CONAHCyT-Instituto Mexicano del Seguro Social, Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Cuauhtémoc, Mexico city, Mexico.ORCID http://orcid.org/0000-0002-7060-6185
Alam Palma-GuzmanInstituto Mexicano del Seguro Social, Laboratorio de Histología, Coordinación de Investigación en Salud, Centro Médico Nacional Siglo XXI, Cuauhtémoc, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-5562-1734
Angélica Coyoy-SalgadoResearchers for Mexico CONAHCyT-Instituto Mexicano del Seguro Social, Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Cuauhtémoc, Mexico city, Mexico.ORCID http://orcid.org/0000-0001-7007-9509
Hermelinda Salgado-CeballosFacultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Estado de Mexico, Mexico. melisalce@yahoo.com.ORCID http://orcid.org/0000-0002-0715-9263
Mexican Social Security Institute · MXUniversidad Nacional Autónoma de México · MXAutonomous University of Tlaxcala · MXInstituto Politécnico Nacional · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mild cognitive impairment (MCI) is defined as inter-stage between normal cognitive aging and major neurocognitive disorder (MND). This state of decay is a crucial factor in treatment to prevent the progression to MND. In this study, our group developed a virtual screening process to evaluate 2568 phytochemical compounds against 5 key proteins associated with MCI and MND. As a result, two potential candidates were identified: carpaine, found in Carica papaya leaves, and punicalagin, present in Punica granatum. A model of cognitive impairment (CI) was developed in 10-month-old male Sprague Dawley rats by administering aluminum chloride (AlCl

Indexed as

CaricaCognitive DysfunctionHydrolyzable TanninsPomegranateAnimalsDisease Models, AnimalMaleMicePhytochemicalsPlant ExtractsRatsRats, Sprague-DawleySeedsHydrolyzable TanninsPhytochemicalsPlant ExtractspunicalaginCarica papayaMajor neurocognitive disorderMild cognitive impairmentNovel object recognition testPhytochemical compoundsPunica granatum

Identifiers

PMID37626269
OpenAlexW4386188108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.