Evidence map›Paper›PMID 37626158›Full record

ArticleEye (London, England)2024

Ocular manifestations and clinical outcomes in Tubulointerstitial Nephritis and Uveitis Syndrome (TINU).

Gunay Uludag Kirimli, Muhammad Hassan, Neil Onghanseng, Chris Or, Cigdem Yasar, Sungwho Park, Amir Akhavanrezayat, Azadeh Mobasserian, Negin Yavari, Vahid Bazojoo and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Gunay Uludag KirimliSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Muhammad HassanSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Neil OnghansengSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Chris OrSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Cigdem YasarSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Sungwho ParkSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.ORCID 0000-0002-9186-2081
Amir AkhavanrezayatSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Azadeh MobasserianSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Negin YavariSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Vahid BazojooSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Hassan KhojastehSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.ORCID 0000-0001-9407-5764
Hashem GhorabaSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.ORCID 0000-0002-1145-4134
Irmak KaracaSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Ngoc Trong Tuong ThanSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Moosa ZaidiSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.ORCID 0000-0003-1788-6306
Quan Dong NguyenSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA. ndquan@stanford.edu.ORCID 0000-0002-6024-8441
Smith-Kettlewell Eye Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the various ocular clinical features and visual outcomes in Tubulointerstitial Nephritis and Uveitis Syndrome (TINU).

methodsThe medical records of 13 patients (26 eyes) diagnosed with TINU were reviewed.

resultsTwenty-six (26) eyes of 13 patients with TINU were reviewed in this study. The median age at onset of uveitis was 14 (range, 9-45). Eight (61.5%) subjects were female. The median follow-up of patients was 30 months (range, 6-89 months). Posterior segment findings were seen in 18 eyes of 9 patients (69.2%). The most common posterior findings were optic nerve head inflammation (16 eyes, 88.8%) and retinal vasculitis (13 eyes, 72.2%). Other posterior findings included vitritis (8 eyes, 44.4%), macular edema (6 eyes, 33.3%), snowball (4 eyes, 22.2%), and chorioretinal lesions (2 eye, 11.1%). Eight patients had fluorescein angiography (FA) data available and most eyes had retinal capillary leakage (13 eyes, 81.2%) followed by optic disc staining/leakage (12 eyes, 75%). Twelve (12) patients (92.3%) were treated with immunomodulatory treatment (IMT) and/or biologics. Five patients (%38.4) required biologics to control intraocular inflammation.

conclusionPosterior segment involvement may be common in patients with TINU syndrome. FA provides significant information for detecting posterior segment involvement and disease activity in TINU. The majority of patients required systemic treatment in order to control intraocular inflammation and prevent relapses.

Indexed as

Biological ProductsNephritis, InterstitialUveitisFemaleHumansInflammationMaleBiological Products

Identifiers

PMID37626158
PMCPMC10810898
OpenAlexW4386162358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.