Evidence map›Paper›PMID 37626143›Full record

ArticleNature communications2023

A transcriptional response to replication stress selectively expands a subset of Brca2-mutant mammary epithelial cells.

Maryam Ghaderi Najafabadi, G Kenneth Gray, Li Ren Kong, Komal Gupta, David Perera, Huw Naylor, Joan S Brugge, Ashok R Venkitaraman, Mona Shehata

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Maryam Ghaderi NajafabadiDepartment of Oncology, University of Cambridge, Cambridge, UK.
G Kenneth GrayDepartment of Cell Biology, Harvard Medical School (HMS), Boston, MA, USA.ORCID http://orcid.org/0000-0003-4969-670X
Li Ren KongMRC Cancer Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-7980-4666
Komal GuptaMRC Cancer Unit, University of Cambridge, Cambridge, UK.
David PereraMRC Cancer Unit, University of Cambridge, Cambridge, UK.
Huw NaylorCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Joan S BruggeDepartment of Cell Biology, Harvard Medical School (HMS), Boston, MA, USA.ORCID http://orcid.org/0000-0002-2547-4814
Ashok R VenkitaramanMRC Cancer Unit, University of Cambridge, Cambridge, UK. arv22@nus.edu.sg.ORCID http://orcid.org/0000-0002-6876-2672
Mona ShehataDepartment of Oncology, University of Cambridge, Cambridge, UK. ms2140@cam.ac.uk.ORCID http://orcid.org/0000-0002-8413-4334
University of Cambridge · GBHarvard University · USNational University of Singapore · SGAgency for Science, Technology and Research · SG

Funding

Cancer Research UK CRI_CORE_LIMIC_2324Medical Research Council MC_UU_12022/1
6 · The paper itself

Abstract

Germline BRCA2 mutation carriers frequently develop luminal-like breast cancers, but it remains unclear how BRCA2 mutations affect mammary epithelial subpopulations. Here, we report that monoallelic Brca2

Indexed as

Epithelial CellsInterferon Type ICell CycleCell ProliferationGene ExpressionInterferon Type I

Identifiers

PMID37626143
PMCPMC10457340
OpenAlexW4386169512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.