Evidence map›Paper›PMID 37626126›Full record

SynthesisInternational journal of obesity (2005)2023

Systemic adiponectin levels in colorectal cancer and adenoma: a systematic review and meta-analysis.

Anne Macleod, Katharina M Scheurlen, James F Burton, Mary Alex Parks, Mst Sharmin Akter Sumy, Jeremy T Gaskins, Susan Galandiuk

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International journal of obesity (2005), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anne MacleodPrice Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA.
Katharina M ScheurlenPrice Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA.
James F BurtonPrice Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA.
Mary Alex ParksPrice Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA.
Mst Sharmin Akter SumyDepartment of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA.
Jeremy T GaskinsDepartment of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA.
Susan GalandiukPrice Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA. s0gala01@louisville.edu.ORCID 0000-0001-9994-5263
University of Louisville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is a well-established risk factor in the development of colorectal cancer; however, the mechanism mediating this relationship is not well understood. The adipokine, adiponectin, has an inverse relationship with obesity. Experimental studies have shown adiponectin to have dichotomous inflammatory and tumorigenic roles. Its role in the development of colorectal cancer, including the potential effect of its increase following bariatric surgery, is not yet clear. There are conflicting results from studies evaluating this relationship. This study sought to provide a systematic review and meta-analysis to examine the association between systemic adiponectin levels in patients with colorectal cancer and adenoma.

methodsAn electronic literature search was performed using PubMed, EMBASE, Web of Science as well as gray literature. Articles were screened for inclusion criteria and assessed for quality using the Newcastle-Ottawa Scale. Pooled mean differences were calculated using a random effects model. Subgroup and meta-regression analyses were performed to identify potential sources of heterogeneity.

resultsThirty-two observational studies comparing systemic adiponectin in colorectal cancer vs healthy controls were included. Colorectal cancer cases had lower systemic adiponectin levels (overall pooled mean difference = -1.05 μg/ml [95% CI: -1.99; -0.12] p = 0.03); however, significant heterogeneity was present (I

conclusionsStudies suggest a trend towards lower systemic adiponectin levels in colorectal cancer patients, but the heterogeneity observed showed current evidence is not sufficient to definitively draw any conclusions. These data, however, suggest rising adiponectin is unlikely to account for the reported observation of increased CRC following bariatric surgery. Further studies with prospective age, race, and BMI-matched cohorts, and standardized adiponectin measurements may provide a better understanding of this relationship.

Indexed as

AdenomaColorectal NeoplasmsAdiponectinHumansObesityProspective StudiesAdiponectin

Identifiers

PMID37626126
OpenAlexW4386162270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.