ArticleChinese journal of traumatology = Zhonghua chuang shang za zhi2024
A newly proposed heatstroke-induced coagulopathy score in patients with heat illness: A multicenter retrospective study in China.
Article in Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- A New Paradigm for Precision Medicine in Heatstroke: From Molecular Subtyping to Targeted Prevention and Treatment.Journal of inflammation research · 2026Review
- Article
- Disseminated intravascular coagulation: cause, molecular mechanism, diagnosis, and therapy.MedComm · 2025Review
- A nomogram based on InLDH and InNLR for predicting disseminated intravascular coagulation in patients with heat stroke.Therapeutic advances in hematology · 2025Article
- Developing a molecular diagnostic model for heatstroke-induced coagulopathy: a proteomics and metabolomics approach.Frontiers in molecular biosciences · 2025Article
- Advances in the comprehensive mechanisms, diagnosis, and treatment of heatstroke-induced coagulopathy.Frontiers in cell and developmental biology · 2025Review
- Article
- [Disseminated intravascular coagulation caused by exertional heat stroke: a case report and literature review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Review
- [Experience summary of coagulation rebalancing therapy for heat stroke-induced coagulopathy].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Article
- Construction and validation of a postoperative hypothermia prediction model in elderly patients undergoing colorectal surgery.Heliyon · 2024Article
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7 authors at 2 institutions in 1 country.
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Abstract
purposeIn patients with heatstroke, disseminated intravascular coagulation (DIC) is associated with greater risk of in-hospital mortality. However, time-consuming assays or a complex diagnostic system may delay immediate treatment. Therefore, the present study proposes a new heatstroke-induced coagulopathy (HIC) score in patients with heat illness as an early warning indicator for DIC.
methodsThis retrospective study enrolled patients with heat illness in 24 Chinese hospitals from March 2021 to May 2022. Patients under 18 years old, with a congenital clotting disorder or liver disease, or using anticoagulants were excluded. Data were collected on demographic characteristics, routine blood tests, conventional coagulation assays and biochemical indexes. The risk factors related to coagulation function in heatstroke were identified by regression analysis, and used to construct a scoring system for HIC. The data of patients who met the diagnostic criteria for HIC and International Society on Thrombosis and Haemostasis defined-DIC were analyzed. All statistical analyses were performed using SPSS 26.0.
resultsThe final analysis included 302 patients with heat illness, of whom 131 (43.4%) suffered from heatstroke, including 7 death (5.3%). Core temperature (OR = 1.681, 95% CI 1.291 - 2.189, p < 0.001), prothrombin time (OR = 1.427, 95% CI 1.175 - 1.733, p < 0.001) and D-dimer (OR = 1.242, 95% CI 1.049 - 1.471, p = 0.012) were independent risk factors for heatstroke, and therefore used to construct an HIC scoring system because of their close relation with abnormal coagulation. A total score ≥ 3 indicated HIC, and HIC scores correlated with the score for International Society of Thrombosis and Hemostasis -DIC (r = 0.8848, p < 0.001). The incidence of HIC (27.5%) was higher than that of DIC (11.2%) in all of 131 heatstroke patients. Meanwhile, the mortality rate of HIC (19.4%) was lower than that of DIC (46.7%). When HIC developed into DIC, parameters of coagulation dysfunction changed significantly: platelet count decreased, D-dimer level rose, and prothrombin time and activated partial thromboplastin time prolonged (p < 0.05).
conclusionsThe newly proposed HIC score may provide a valuable tool for early detection of HIC and prompt initiation of treatment.
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