Evidence map›Paper›PMID 37625781›Full record

ArticleProstaglandins & other lipid mediators2023

A novel HSPB1

Keila S Espinoza, Kyra N Hermanson, Cameron A Beard, Nicholas U Schwartz, Justin M Snider, Benjamin E Low, Michael V Wiles, Yusuf A Hannun, Lina M Obeid, Ashley J Snider

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostaglandins & other lipid mediators, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Keila S EspinozaDepartment of Physiology, University of Arizona, Tucson, AZ 85721, USA.
Kyra N HermansonDepartment of Physiology, University of Arizona, Tucson, AZ 85721, USA.
Cameron A BeardSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ 85721, USA.
Nicholas U SchwartzDepartment of Neurology, Stanford University Medical Center, Stanford, CA 94304, USA.
Justin M SniderSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ 85721, USA; University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85721, USA.
Benjamin E LowTechnology Evaluation and Development, The Jackson Laboratory, Bar Harbor, ME, USA; Genetic Resource Science, The Jackson Laboratory, Bar Harbor, ME, USA.
Michael V WilesTechnology Evaluation and Development, The Jackson Laboratory, Bar Harbor, ME, USA.
Yusuf A HannunDepartment of Medicine and Stony Brook Cancer Center, Stony Brook, NY 11794, USA; Northport Veterans Affairs Medical Center, Northport, NY 11768, USA.
Lina M ObeidDepartment of Medicine and Stony Brook Cancer Center, Stony Brook, NY 11794, USA; Northport Veterans Affairs Medical Center, Northport, NY 11768, USA.
Ashley J SniderSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ 85721, USA; University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85721, USA. Electronic address: ashleysnider@arizona.edu.
University of Arizona · USJackson Laboratory · USNorthport VA Medical Center · USStanford University · USUniversity of Arizona Cancer Center

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
Sphingolipids in Cancer Therapy and AngiogenesisP01CA097132 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI YUSUF AWNI HANNUN · 2003 to 2026
$30.8M
Novel Mouse Model for Charcot-Marie Tooth DiseaseR03NS111420 · NINDS · UNIVERSITY OF ARIZONA · PI SNIDER, ASHLEY JONES · 2020 to 2020
$154k
NCI NIH HHS P01 CA097132NCI NIH HHS P30 CA023074NINDS NIH HHS R03 NS111420
6 · The paper itself

Abstract

Charcot-Marie-Tooth Disease (CMT) is a commonly inherited peripheral polyneuropathy. Clinical manifestations for this disease include symmetrical distal polyneuropathy, altered deep tendon reflexes, distal sensory loss, foot deformities, and gait abnormalities. Genetic mutations in heat shock proteins have been linked to CMT2. Specifically, mutations in the heat shock protein B1 (HSPB1) gene encoding for heat shock protein 27 (Hsp27) have been linked to CMT2F and distal hereditary motor and sensory neuropathy type 2B (dHMSN2B) subtype. The goal of the study was to examine the role of an endogenous mutation in HSPB1 in vivo and to define the effects of this mutation on motor function and pathology in a novel animal model. As sphingolipids have been implicated in hereditary and sensory neuropathies, we examined sphingolipid metabolism in central and peripheral nervous tissues in 3-month-old Hsp

Indexed as

Charcot-Marie-Tooth DiseaseAnimalsDisease Models, AnimalHeat-Shock ProteinsMiceMutationSphingolipidsHeat-Shock ProteinsSphingolipidsAcetylated α-tubulinCeramide synthase (CerS)Charcot-Marie-Tooth 2F (CMT2F)Hereditary sensory and autonomic neuropathy type 1 (HSAN1)Phospho-neurofilament

Identifiers

PMID37625781
PMCPMC10843462
OpenAlexW4386102862

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.