Evidence map›Paper›PMID 37625385›Full record

ArticleAnnals of medicine2023

Effects of bright light therapy on neuroinflammatory and neuroplasticity markers in a diurnal rodent model of Seasonal Affective Disorder.

Allison Costello, Katrina Linning-Duffy, Carleigh Vandenbrook, Joseph S Lonstein, Lily Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Allison CostelloDepartment of Psychology, MI State University, MI, USA.ORCID 0000-0001-7119-3194
Katrina Linning-DuffyDepartment of Psychology, MI State University, MI, USA.
Carleigh VandenbrookDepartment of Psychology, MI State University, MI, USA.
Joseph S LonsteinDepartment of Psychology, MI State University, MI, USA.ORCID 0000-0003-4325-9605
Lily YanDepartment of Psychology, MI State University, MI, USA.ORCID 0000-0002-6261-2542
Michigan State University · US

Funding

Neural Basis of Light-dependent Depression and AnxietyR01MH111276 · NIMH · MICHIGAN STATE UNIVERSITY · PI LONSTEIN, JOSEPH S, YAN, LILY · 2016 to 2020
$1.9M
Diurnal Experimental Models to Investigate Neural Mechanisms of Sleep Disturbance in Smith-Magenis SyndromeR21NS125449 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI IWASE, SHIGEKI, YAN, LILY · 2021 to 2021
$444k
NIMH NIH HHS R01 MH111276NINDS NIH HHS R21 NS125449
6 · The paper itself

Abstract

backgroundBright light therapy (BLT) is widely used for treating Seasonal Affective Disorder (SAD). However, the neural mechanisms underlying the therapeutic effects of BLT remain largely unexplored. The present study used a diurnal rodent (Nile grass rats; MATERIALS AND

methodsIn the present study, male and female grass rats were housed under the winter-like dim daytime light condition (lights on 600-1800 hr, 50 lux). The experimental groups received daily 1-h early morning BLT from 0600-0700 using full-spectrum light (10,000 lux), while the control groups received narrowband red light (λmax, 780 nm). Following 4 weeks of treatment, the expression of several neuroinflammatory or plasticity markers was examined in the medial prefrontal cortex (mPFC), basolateral amygdala (BLA), and the CA1 of the dorsal hippocampus.

resultsFor the neuroinflammatory markers, BLT reduced TNF-α in the BLA of females, and upregulated CD11b in the mPFC and IL6 in the BLA in males. For the neuroplasticity markers, BLT downregulated BDNF in the CA1 and TrkB in all three brain regions in females but upregulated BDNF in the BLA and CA1 in males.

conclusionsThese results indicate that the therapeutic effects of BLT on sleep, mood, and cognition may be attributed in part to mechanisms involving neuroinflammation and neuroplasticity in corticolimbic brain regions. Moreover, these effects appear to vary between sexes.

Indexed as

GlomerulonephritisSeasonal Affective DisorderAnimalsBrain-Derived Neurotrophic FactorFemaleHumansMaleMurinaeNeuroinflammatory DiseasesPhototherapyBrain-Derived Neurotrophic FactorAmygdalabDNFCD11bcortexdaylightdepressionhippocampustNFTrkBα IL6

Identifiers

PMID37625385
PMCPMC10461522
OpenAlexW4386155115

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.