Evidence map›Paper›PMID 37625344›Full record

ReviewCurrent opinion in neurobiology2023

Persistent modulatory actions and task switching in the feeding network of Aplysia.

Elizabeth C Cropper, Matthew Perkins, Jian Jing

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elizabeth C CropperDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: Elizabeth.cropper@gmail.com.
Matthew PerkinsDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Jian JingDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; State Key Laboratory of Pharmaceutical Biotechnology, Institute for Brain Sciences, Chemistry and Biomedicine Innovation Center, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Advanced Institute for Life Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.

Funding

Neural Basis of Behavioral ArousalR01NS066587 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CROPPER, ELIZABETH C · 2009 to 2023
$5.2M
Neural Basis of Behavioral FlexibilityR01NS070583 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CROPPER, ELIZABETH C, WEISS, KLAUDIUSZ ROBERT · 2010 to 2020
$3.6M
A novel approach to analyzing functional connectomics and combinatorial control in a tractable small-brain closed-loop systemRF1NS118606 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BYRNE, JOHN H, CHESTEK, CYNTHIA ANNE · 2020 to 2020
$3.0M
A novel approach to analyzing functional connectomics and combinatorial control in a tractable small-brain closed-loop systemR01NS118606 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BYRNE, JOHN H, CHESTEK, CYNTHIA ANNE · 2023 to 2024
$1.7M
NINDS NIH HHS R01 NS066587NINDS NIH HHS R01 NS070583NINDS NIH HHS R01 NS118606NINDS NIH HHS RF1 NS118606
6 · The paper itself

Abstract

The activity of multifunctional networks is configured by neuromodulators that exert persistent effects. This raises a question, does this impact the ability of a network to switch from one type of activity to another? We review studies that have addressed this question in the Aplysia feeding circuit. Task switching in this system occurs "asymmetrically." When there is a switch from egestion to ingestion neuromodulation impedes switching (creates a "negative bias"). When there is a switch from ingestion to egestion the biasing is "positive." Ingestion promotes subsequent egestion. We contrast mechanisms responsible for the two types of biasing and show that the observed asymmetry is a consequence of the fact that there is more than one set of egestive circuit parameters.

Indexed as

AplysiaFeeding BehaviorAnimals

Identifiers

PMID37625344
PMCPMC10530010

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.