Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2023
Financial Toxicity Monitoring in a Randomized Controlled Trial of Patient-Reported Outcomes During Cancer Treatment (Alliance AFT-39).
Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Symptom monitoring with electronic patient-reported outcomes during cancer treatment: final results of the PRO-TECT cluster-randomized trial.Nature medicine · 2025Trial
- Financial Toxicity Among Disaggregated Asian American Cancer Survivors.JAMA network open · 2026Article
- Addressing financial and health-related social needs among patients with cancer: Study protocol for CAN-ASSIST pilot clinical trial.Contemporary clinical trials communications · 2026Article
- ASO Education and Training: Taking the Next Step in Surgical Oncology Health Disparities Research: Identifying Root Causes and Targets for Actionable Change.Annals of surgical oncology · 2026Review
- Longitudinal Associations Between Financial Toxicity and Health-Related Quality of Life for Patients With Cancer.JCO oncology practice · 2026Article
- Associations between psychological distress and financial hardship for patients with cancer receiving care in Alabama.Journal of cancer survivorship : research and practice · 2026Article
- Application of digital health interventions in the management of economic toxicity in cancer patients: a scoping review.Frontiers in public health · 2026Article
- Family Experiences of Financial Hardship after Critical Illness.Annals of the American Thoracic Society · 2025Article
- A Scoping Review of Interventions to Address Financial Toxicity in Pediatric and Adult Patients and Survivors of Cancer.Cancer medicine · 2025Article
- Development of A Caregiver-Reported Scale for Pediatric Cancer Financial Toxicity (CRS-PCFT).Cancer medicine · 2025Article
- Interventions to Address Cancer-Related Financial Hardship: A Scoping Review and Call to Action.JCO oncology practice · 2025Article
- Development and Validation of a Simplified Financial Toxicity Screening Tool for Use in Clinical Practice.JCO oncology practice · 2025Article
- Financial Toxicity in Older Adults With Cancer and Their Caregivers.JCO oncology practice · 2025Review
- Exploring the Relationship Among Financial Hardship, Anxiety, and Depression in Patients With Cancer: A Longitudinal Study.JCO oncology practice · 2024Article
- A Qualitative Study of Electronic Patient-Reported Outcome Symptom Monitoring After Thoracic Surgery.The Journal of surgical research · 2024Article
- Article
- Digital symptom assessment tools: the next frontier in financial toxicity screening.Nature reviews. Clinical oncology · 2024Article
- Care Delivery Interventions for Individuals with Cancer: A Literature Review and Focus on Gastrointestinal Malignancies.Healthcare (Basel, Switzerland) · 2023Review
- Financial toxicity in cancer patients and subsequent risk of repeat acute care utilization.Frontiers in psychology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 6 institutions in 1 country.
Funding
Abstract
purposeFinancial toxicity (FT) affects 20% of cancer survivors and is associated with poor clinical outcomes. No large-scale programs have been implemented to mitigate FT. We evaluated the effect of monthly FT screening as part of a larger patient-reported outcomes (PROs) digital monitoring intervention.
methodsPRO-TECT (AFT-39) is a cluster-randomized trial of patients undergoing systemic therapy for metastatic cancer. Practices were randomly assigned 1:1 to digital symptom monitoring (PRO practices) or usual care (control practices). Digital monitoring consisted of between-visit online or automated telephone patient surveys about symptoms, functioning, and FT (single-item screening question from Functional Assessment of Chronic Illness Therapy-COmprehensive Score for financial Toxicity) for up to 1 year, with automated alerts sent to practice nurses for concerning survey scores. Clinical team actions in response to alerts were not mandated. The primary outcome of this planned secondary analysis was development or worsening of financial difficulties, assessed via the European Organisation for Research and Treatment of Cancer QLQ-C30 financial difficulties measure, at any time compared with baseline. A randomly selected subset of patients and nurses were interviewed about their experiences with the intervention.
resultsOne thousand one hundred ninety-one patients were enrolled (593 PRO; 598 control) at 52 US community oncology practices. Overall, 30.2% of patients treated at practices that received the FT screening intervention developed, or experienced worsening of, financial difficulties, compared with 39.0% treated at control practices (
conclusionIn this report of a secondary outcome from a randomized clinical trial, FT screening as part of routine digital patient monitoring with PROs reduced the development, or worsening, of financial difficulties among patients undergoing systemic cancer therapy.
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