ArticleScience immunology2023
Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 65 citations in OpenAlex.
- PD-1⁺ CD8⁺ T cells: roles of PD-1 beyond an exhaustion marker.Seminars in immunopathology · 2026Review
- Immune profile and mitochondrial alterations driven by age and HIV infection: Associations with T-cell senescence in people with HIV receiving suppressive antiretroviral therapy.Virologica Sinica · 2026Article
- T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- GM-CSF Promotes Superior In Vitro Differentiation of MHC IIInternational journal of molecular sciences · 2026Article
- Functional Type I and Type II interferon crosstalk restricts progenitor exhausted CD8 T cells through spatial exclusion and checkpoint enforcement.bioRxiv : the preprint server for biology · 2026Article
- PD-1 protects expanding human T cells from premature restimulation-induced cell death by modulating TCR and CD28 signaling.Cell death & disease · 2026Article
- Regulators of CD8Nature reviews. Immunology · 2026Review
- Checkpoint-enriched T cells with retained effector-associated features are associated with disease activity in systemic lupus erythematosus.Frontiers in immunology · 2026Article
- AblatingFrontiers in immunology · 2026Article
- Modular delivery of co-stimulatory signals through a PD-1-based immunoswitch receptor improves the functionality of Hepatitis B Virus-specific engineered T cells.Frontiers in immunology · 2026Article
- Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026Article
- Causal relationship between palmitoylation genes mediated by immune cell phenotypes and oral cancer: A Mendelian randomized study.Medicine · 2025Article
- CD7 regulates the persistence of terminally exhausted CD8Cell reports · 2025Article
- Lymph nodes fuel KLF2-dependent effector CD8Nature immunology · 2025Article
- Regulation of TCR-induced Transcriptional Kinetics by Interleukin 2-inducible T Cell Kinase (ITK) in CD8bioRxiv : the preprint server for biology · 2025Article
- Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment.Cell reports. Medicine · 2025Article
- Understanding the HIV-specific T-cell response to immune checkpoint blockade: what can we learn from cancer immunotherapy?Current opinion in HIV and AIDS · 2025Review
- The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1Immunity · 2025Article
- Bi-directional metabolic reprogramming between cancer cells and T cells reshapes the anti-tumor immune response.PLoS biology · 2025Article
- Transitioning from native to synthetic receptors: broadening T-cell engineering and beyond.Cellular & molecular immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 8 institutions in 4 countries.
Etienne HumblinMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0000-0002-4559-6106
Isabel KorpasMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0009-0005-5392-6960
Jiahua LuMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0000-0001-8544-891X
Dan FilipescuDepartment of Oncological Sciences, ISMMS, New York, NY 10029, USA.ORCID 0000-0001-6381-2557
Verena van der HeideMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0000-0002-3602-4405
Simon GoldsteinMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0009-0008-1259-4017
Abishek VaidyaMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0000-0001-8458-7950
Alessandra Soares-SchanoskiMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0000-0002-6514-8458
Beatrice CasatiMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0000-0001-8516-5792
Myvizhi E SelvanDepartment of Genetics and Genomics, ISMMS, New York, NY 10029, USA.ORCID 0000-0003-4640-5727
Zeynep H GümüşMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0000-0002-7364-2202
Andreas WielandDepartment of Otolaryngology-Head and Neck Surgery and Pelotonia Institute for Immuno-Oncology, OSUCCC-James, Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-9648-7922
Mauro CorradoCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine (CMMC) and Institute for Genetics, University of Cologne, 50931 Cologne, Germany.ORCID 0000-0002-0617-3274
Leona Cohen-GouldDepartment of Biochemistry, Weill Cornell Medical College, New York, NY 10029, USA.ORCID 0000-0001-7081-7268
Emily BernsteinDepartment of Oncological Sciences, ISMMS, New York, NY 10029, USA.ORCID 0000-0001-6533-8326
Dirk HomannMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0000-0002-7622-5754
Jerry ChipukDepartment of Oncological Sciences, ISMMS, New York, NY 10029, USA.ORCID 0000-0002-1337-842X
Alice O KamphorstMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0000-0002-9230-9501
Icahn School of Medicine at Mount Sinai · USTisch Hospital · USInstitut thématique Génétique, génomique et bioinformatique · FRCenter for Migration Studies of New York · USCologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · DECornell University · USInstitute of Nutrition, Metabolism and Diabetes · CAThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US
Funding
THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4MDeciphering the tumor suppressive functions of macroH2AR01CA154683 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BERNSTEIN, EMILY · 2011 to 2021
$3.9MDeterminants of differentiation and maintenance of PD-1+ CD8 T cellsR01AI153363 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KAMPHORST, ALICE OLIFFSON · 2021 to 2025
$3.3MChronic Mitochondrial Division and Melanoma: Mechanism, Prognosis, and TherapyR01CA267696 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jerry Edward Chipuk · 2022 to 2026
$2.4MThe Oncogene Activated Mitochondrial Unfolded Protein Response Regulates Senescence BiologyR01CA271346 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jerry Edward Chipuk · 2023 to 2026
$2.4MFunction and Regulation of the BCL-2 FamilyR01CA237264 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHIPUK, JERRY EDWARD · 2020 to 2024
$1.9MPRIMAVO: Interactive exploration of cancer patient precision immune monitoring data in clinical trialsR33CA263705 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GUMUS, ZEYNEP HULYA · 2021 to 2021
$1.5MNCI NIH HHS P30 CA196521NCI NIH HHS R01 CA154683NCI NIH HHS R01 CA237264NCI NIH HHS R01 CA267696NCI NIH HHS R01 CA271346NCI NIH HHS R33 CA263705NIAID NIH HHS R01 AI153363
Abstract
During persistent antigen stimulation, such as in chronic infections and cancer, CD8 T cells differentiate into a hypofunctional programmed death protein 1-positive (PD-1
Indexed as
CD28 AntigensT Cell Transcription Factor 1CD8-Positive T-LymphocytesCell DifferentiationProgrammed Cell Death 1 ReceptorTranscription FactorsCD28 AntigensProgrammed Cell Death 1 ReceptorT Cell Transcription Factor 1Transcription Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.