ArticleScience advances2023
Human REM sleep recalibrates neural activity in support of memory formation.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Trial
- Article
- Potential mechanisms and functional significance of aperiodic neural activity.Nature human behaviour · 2026Review
- Sleep Deprivation in Mice: Looking Beyond the Slow Wave Rebound.Journal of sleep research · 2026Article
- Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer's disease-related hyperexcitability and brain network dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Article
- Aperiodic and periodic neural activity during sleep in autism spectrum disorders.BMC medicine · 2026Article
- How to Improve the Reliability of Aperiodic Parameter Estimates in M/EEG: A Method Comparison.Psychophysiology · 2026Article
- Aperiodic 1/f noise drives ripple activity in humans.Nature communications · 2026Article
- Aperiodic Activity Reflects Pathologic Waveform Shapes in Focal Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Temporally resolved analyses of aperiodic features track neural dynamics during sleep.Communications psychology · 2025Article
- How to Improve the Reliability of Aperiodic Parameter Estimates in M/EEG: A Method Comparison and Recommendations for Best Practices.bioRxiv : the preprint server for biology · 2025Article
- Distinct manifestations of excitatory-inhibitory imbalance associated with amyloid-β and tau in patients with Alzheimer's disease.Nature communications · 2025Article
- Wake EEG oscillation dynamics reflect both sleep pressure and brain maturation across childhood and adolescence.bioRxiv : the preprint server for biology · 2025Article
- Personalized targeted memory reactivation enhances consolidation of challenging memories via slow wave and spindle dynamics.NPJ science of learning · 2025Article
- Article
- Realistic Subject-Specific Simulation of Resting State Scalp EEG Based on Physiological Model.Brain topography · 2025Article
- Excitatory/Inhibitory imbalance as a mechanism linking autism and sleep problems.Current opinion in neurobiology · 2025Review
- Targeted-Modified MultiTransm Microelectrode Arrays Simultaneously Track Dopamine and Cellular Electrophysiology in Nucleus Accumbens during Sleep-Wake Transitions.Research (Washington, D.C.) · 2025Article
- Multi-region processing during sleep for memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
The proposed mechanisms of sleep-dependent memory consolidation involve the overnight regulation of neural activity at both synaptic and whole-network levels. Now, there is a lack of in vivo data in humans elucidating if, and how, sleep and its varied stages balance neural activity, and if such recalibration benefits memory. We combined electrophysiology with in vivo two-photon calcium imaging in rodents as well as intracranial and scalp electroencephalography (EEG) in humans to reveal a key role for non-oscillatory brain activity during rapid eye movement (REM) sleep to mediate sleep-dependent recalibration of neural population dynamics. The extent of this REM sleep recalibration predicted the success of overnight memory consolidation, expressly the modulation of hippocampal-neocortical activity, favoring remembering rather than forgetting. The findings describe a non-oscillatory mechanism how human REM sleep modulates neural population activity to enhance long-term memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.