Observational studyAmerican journal of respiratory and critical care medicine2023
Augmentation Therapy for Severe Alpha-1 Antitrypsin Deficiency Improves Survival and Is Decoupled from Spirometric Decline-A Multinational Registry Analysis.
Registry-linked trialOpen access · hybridAbstract readObservational Study
In one paragraph
Observational study in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07715617 (Development of a Prediction Score for the Occurrence of Death or Lung Transplantation in Patients With Emphysema Secondary to Alpha-1-anti-tripsin Deficiency), which is not on this map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of a Prediction Score for the Occurrence of Death or Lung Transplantation in Patients With Emphysema Secondary to Alpha-1-anti-tripsin Deficiency
Who cites it
38 citing papers in PubMed, 48 citations in OpenAlex.
- Two randomised controlled phase 2 studies of the oral neutrophil elastase inhibitor alvelestat in alpha-1 antitrypsin deficiency.The European respiratory journal · 2025Trial
- α1-Antitrypsin attenuates microglial NLR family pyrin domain containing 3 inflammasome activation via cannabinoid receptor 2 signaling to ameliorate α-synucleinopathy-related behavioral deficits.Molecular biomedicine · 2026Article
- Advancing Precision Approaches to Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2026Review
- Delayed Diagnosis of Alpha-1 Antitrypsin Deficiency in an Elderly Patient.Diagnostics (Basel, Switzerland) · 2026Article
- Alpha-1 Antitrypsin Deficiency: Current Landscape of Detection, Management, and Treatment.Advances in therapy · 2026Review
- Alpha-1 Antitrypsin Deficiency-Associated Chronic Obstructive Pulmonary Disease.Medicina (Kaunas, Lithuania) · 2026Review
- Clinical implications of a novel SERPINA1 variant c.236 T > A: Challenges in characterizing new rare alpha-1 antitrypsin mutations.Molecular genetics and metabolism reports · 2026Article
- Characteristics of bronchiectasis in patients with different genotypes of severe αERJ open research · 2026Article
- The Role of Alpha-1 Antitrypsin in the Pathophysiology and Treatment of Inflammatory Lung Diseases.Journal of inflammation research · 2026Review
- Phenotypic Expression of Respiratory Diseases and Tailored Treatment in Patients with Intermediate Alpha-1 Antitrypsin Deficiency: Evidence from a Retrospective Analysis of a Selected Cohort of Patients.Medicina (Kaunas, Lithuania) · 2025Article
- Clinical characteristics of AATD-related COPD patients vary with age at diagnosis: data from the EARCO international registry.BMC pulmonary medicine · 2025Article
- Longitudinal Outcomes in Pi*MZ Alpha-1 Antitrypsin-Deficient Individuals with Tobacco Smoking History from the SPIROMICS Cohort.Annals of the American Thoracic Society · 2025Article
- Further Insights into Emphysema Progression and Lung Function Decline in MZ Alpha-1 Antitrypsin Deficiency.Annals of the American Thoracic Society · 2025Article
- Contemporary Concise Review 2024: Chronic Obstructive Pulmonary Disease.Respirology (Carlton, Vic.) · 2025Review
- Increasing Quality and Quantity of Life in Individuals with Chronic Obstructive Pulmonary Disease: A Narrative Review with an Emphasis on Pulmonary Rehabilitation.Life (Basel, Switzerland) · 2025Review
- Alpha-1 antitrypsin deficiency-associated liver disease: From understudied disorder to the poster child of genetic medicine.Hepatology communications · 2025Review
- Review
- Improving the Likelihood of Identifying Alpha-1 Antitrypsin Deficiency Among Patients With COPD: A Novel Predictive Model Using Real-World Data.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Response to: risk of lung disease with the Pi*SS genotype of alpha-1 antitrypsin: the evidence in context.Respiratory research · 2025Article
- Advances on the Role of Lung Macrophages in the Pathogenesis of Chronic Obstructive Pulmonary Disease in the Era of Single-Cell Genomics.International journal of medical sciences · 2025Review
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 4 countries.
Daniel D FraughenDepartment of Medicine, Irish Center for Genetic Lung Disease, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0001-9876-4938
Auyon J GhoshDivision of Pulmonary, Critical Care, and Sleep Medicine, SUNY Upstate University Hospital, Syracuse, New York.ORCID 0000-0003-0334-4039
Brian D HobbsChanning Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0001-9564-0745
Georg-Christian FunkKarl Landsteiner Institute for Lung Research and Pulmonary Oncology and Department of Medicine II with Pneumology, Klinik Ottakring, Vienna, Austria.ORCID 0000-0002-2891-0271
Tobias MeischlKarl Landsteiner Institute for Lung Research and Pulmonary Oncology and Department of Medicine II with Pneumology, Klinik Ottakring, Vienna, Austria.ORCID 0000-0002-1716-9166
Christian F ClarenbachDepartment of Pneumology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-2158-2321
Noriane A SieviDepartment of Pneumology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-1758-4586
Karin Schmid-ScherzerKarl Landsteiner Institute for Lung Research and Pulmonary Oncology and Department of Medicine II with Pneumology, Klinik Ottakring, Vienna, Austria.
Oliver J McElvaneyDepartment of Medicine, Irish Center for Genetic Lung Disease, Royal College of Surgeons in Ireland, Dublin, Ireland.
Mark P MurphyDepartment of Medicine, Irish Center for Genetic Lung Disease, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0001-5624-1338
Adam D RocheDepartment of Medicine, Irish Center for Genetic Lung Disease, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0002-0913-3550
Louise ClarkeDepartment of Respiratory Physiology, Beaumont Hospital, Dublin, Ireland; and.
Matthew StrandDivision of Biostatistics and Bioinformatics, National Jewish Health, Denver, Colorado.ORCID 0000-0002-9083-5989
Florian Vafai-TabriziKarl Landsteiner Institute for Lung Research and Pulmonary Oncology and Department of Medicine II with Pneumology, Klinik Ottakring, Vienna, Austria.ORCID 0000-0001-5872-1140
Geraldine KellyDepartment of Medicine, Irish Center for Genetic Lung Disease, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0009-0009-1241-2540
Cedric GunaratnamDepartment of Respiratory Physiology, Beaumont Hospital, Dublin, Ireland; and.ORCID 0009-0003-0318-1484
Tomás P CarrollDepartment of Medicine, Irish Center for Genetic Lung Disease, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0002-0418-1641
Noel G McElvaneyDepartment of Medicine, Irish Center for Genetic Lung Disease, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0002-0152-4370
Royal College of Surgeons in Ireland · IEKarl Landsteiner Society · ATBeaumont Hospital · IEUniversity Hospital of Zurich · CHBrigham and Women's Hospital · USNational Jewish Health · USSUNY Upstate Medical University · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
alpha 1-Antitrypsin DeficiencyPulmonary Disease, Chronic ObstructiveAdultalpha 1-AntitrypsinHumansLungMiddle AgedPhenotypeRegistriesYoung Adultalpha 1-AntitrypsinSERPINA1 protein, humanforced expiratory volumeKaplan-Meier survival curveuniversal health careα 1-proteinase inhibitor
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT07715617ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.