Evidence map›Paper›PMID 37624698›Full record

ArticleCell reports2023

Development of nanoRibo-seq enables study of regulated translation by cortical neuron subtypes, showing uORF translation in synaptic-axonal genes.

John E Froberg, Omer Durak, Jeffrey D Macklis

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

John E FrobergDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Omer DurakDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Jeffrey D MacklisDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Electronic address: jeffreymacklis@fas.harvard.edu.
Harvard University · US

Funding

Training in the Molecular Biology of Neurodegeneration and Alzheimer's DiseaseT32AG000222 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Bruce A YANKNER · 1992 to 2026
$18.5M
Subcellular RNA-Proteome Mapping in Subtype- and Circuit-Specific Growth Cones: Development, Cell Biology, Disease, and RegenerationDP1NS106665 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2017 to 2021
$5.9M
Molecular Controls over Neurogenesis, Subtype Development, and Diversity of Cortical Output Projection NeuronsR01NS045523 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2002 to 2020
$5.4M
Molecular Development and Diversity of Callosal Projection NeuronsR01NS104055 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2020 to 2024
$1.9M
Regulation of cortical circuit formation by subcellular compartmentalization of mRNA translationF32AG067661 · NIA · HARVARD UNIVERSITY · PI FROBERG, JOHN · 2021 to 2022
$140k
NIA NIH HHS F32 AG067661NIA NIH HHS T32 AG000222NINDS NIH HHS DP1 NS106665NINDS NIH HHS R01 NS045523NINDS NIH HHS R01 NS104055
6 · The paper itself

Abstract

Investigation of translation in rare cell types or subcellular contexts is challenging due to large input requirements for standard approaches. Here, we present "nanoRibo-seq" an optimized approach using 10

Indexed as

AxonsNeuronsCorpus CallosumOpen Reading FramesProtein BiosynthesisRibosomesRNA, MessengerRNA, Messengercallosal projection neuronscortical developmentCP: Neurosciencemolecular controls over neuronal diversitymRNA translationRibo-seqribosomeribosome profilingsubcerebral projection neuronstranslational regulationupstream open reading frame (uORF)

Identifiers

PMID37624698
PMCPMC10591829
OpenAlexW4386130133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.