Evidence map›Paper›PMID 37624689›Full record

ArticleJournal of child neurology2023

Continuous Electroencephalography (EEG) Protocol Improves Seizure Detection in Children on Extracorporeal Membrane Oxygenation.

Danielle deCampo, Khalil S Husari, Melania M Bembea, Christa W Habela, Eva K Ritzl

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Article in Journal of child neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Danielle deCampoDepartments of Neurology, Johns Hopkins Hospital, Baltimore, MD, USA.
Khalil S HusariDepartments of Neurology, Johns Hopkins Hospital, Baltimore, MD, USA.
Melania M BembeaDepartment of Anesthesiology and Critical Care, Johns Hopkins Hospital, Baltimore, MD, USA.
Christa W HabelaDepartments of Neurology, Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0002-5315-2310
Eva K RitzlDepartments of Neurology, Johns Hopkins Hospital, Baltimore, MD, USA.

Funding

Biomarkers of Brain Injury in Critically-Ill Children on Extracorporeal Membrane Oxygenation (ECMO)R01NS106292 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BEMBEA, MELANIA MARIA · 2019 to 2023
$3.1M
Modeling genetic risk for epilepsy using IPSC and animal models.K08NS102526 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HABELA, CHRISTA · 2020 to 2024
$996k
NINDS NIH HHS K08 NS102526NINDS NIH HHS R01 NS106292
6 · The paper itself

Abstract

BACKGROUND /

objectiveSeizures are a complication for pediatric patients requiring extracorporeal membrane oxygenation (ECMO). There are no standardized guidelines regarding continuous electroencephalography (EEG) monitoring to detect seizures in these patients, and the impact of protocolized monitoring has not been evaluated. Here we examined the effects of continuous EEG protocol implementation in our pediatric ECMO population.

methodsRetrospective chart reviews were conducted on 57 patients who underwent extracorporeal membrane oxygenation and concurrent continuous EEG out of 165 patients supported on extracorporeal membrane oxygenation. Timing of continuous EEG initiation and seizures detected by continuous EEG was determined for 5 years prior to and 15 months after protocol implementation.

resultsProtocol implementation was associated with increased ECMO-supported patients who were concurrently monitored by continuous EEG. Time from ECMO cannulation to continuous EEG initiation was shorter (median 7 hours after versus 16.2 hours before;

conclusionsProtocol implementation resulted in earlier continuous EEG initiation and more EEGs initiated before seizure onset with evidence of altered seizure dynamics. Although current recommendations suggest that continuous EEG duration of 24-48 hours results in seizure detection for >90% of critically ill adults, longer monitoring may be needed to reliably detect seizures in children supported with ECMO, particularly if monitoring is initiated earlier in the post-cannulation period.

Indexed as

Extracorporeal Membrane OxygenationStatus EpilepticusAdultChildElectroencephalographyHumansRetrospective StudiesSeizuresEEGelectroencephalographyseizuresstatus epilepticus

Identifiers

PMID37624689
PMCPMC11060699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.