Evidence map›Paper›PMID 37624543›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Quality control in treating patients with patent foramen ovale: 7-year-experience of the Heart and Brain team of the Careggi University Hospital.

Francesco Meucci, Costanza Maria Rapillo, Miroslava Stolcova, Giulia Domna Scrima, Giulia Nardi, Rita Nistri, Francesca Ristalli, Nicoletta D'Ettore, Alessio Mattesini, Francesco Buonamici and 8 more

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Treatment of patent foramen ovale.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
    Review
  3. How a good laugh can get scary: a case of gelastic stroke-looking for clues of PFO-related events.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Francesco MeucciStructural Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Costanza Maria RapilloNEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy. costanzamaria.rapillo@unifi.it.ORCID http://orcid.org/0000-0002-6380-6373
Miroslava StolcovaStructural Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Giulia Domna ScrimaNEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.
Giulia NardiStructural Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Rita NistriDepartment of Heart and Vessel, Careggi University Hospital, Florence, Italy.
Francesca RistalliStructural Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Nicoletta D'EttoreStructural Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Alessio MattesiniStructural Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Francesco BuonamiciDepartment of Industrial Engineering, University of Florence, Florence, Italy.
Benedetta PiccardiStroke Unit, Careggi University Hospital, Florence, Italy.
Laura TudiscoStroke Unit, Careggi University Hospital, Florence, Italy.
Antonella CramaroNeurosonology Unit, Careggi University Hospital, Florence, Italy.
Sara TrapaniNeurosonology Unit, Careggi University Hospital, Florence, Italy.
Giovanni PracucciNEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.
Patrizia NenciniStroke Unit, Careggi University Hospital, Florence, Italy.
Carlo Di MarioStructural Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Cristina SartiNEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe right comprehension of ischemic stroke pathogenesis guarantees the best prevention therapy. The term "patent foramen ovale (PFO) related stroke" has been proposed for those events where PFO is supposed to be pathogenetic, but their definition is challenging. A multidisciplinary evaluation in a "Heart & Brain" team (HBteam) including stroke neurologists and interventional cardiologists was therefore highly recommended in the recent guidelines of secondary stroke prevention.

objectiveWe aimed at describing the organization of the HBteam of Careggi-University-Hospital of Florence (Italy), and the results of the first seven years of activity.

methodsIn 2016 Interventional Cardiologists and Stroke Neurologists set up an outpatient clinic for the joined evaluation of patients with PFO and other cardio/neurological conditions. A specific diagnostic-therapeutic hospital plan was produced for PFO patients. Patient empowerment was guaranteed by a hospital explicative webpage, a booklet regarding risks/benefits of PFO closure and a 3D heartmodel to simulate the intervention. Data were collected in a dedicated registry.

resultsWe evaluated 594 patients for PFO, 40 for left atrial appendage closure and 38 for other conditions. In 20% of PFO-patients, HBteam diagnosis was discordant from that of referring physicians, 14% were stroke misdiagnoses. We advised against closure in 53% of patients. At follow-up 94% of closed patients had no/minimum residual shunt; 3 patients had a cerebral ischemic event.

conclusionsA dedicated HBteam represents a unique opportunity to share decisions with patients after a thorough empowerment process. The joining of cardioneurological skills allows a better classification of PFO-patients, reducing futile interventions.

Indexed as

Foramen Ovale, PatentStrokeBrainHospitalsHumansNeoplasm Recurrence, LocalQuality ControlRecurrenceSecondary PreventionTreatment OutcomeClosureHeart and brain teamIschemic strokeMultidisciplinaryPatent foramen ovalePFO

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.