SynthesisJournal of neuro-oncology2023
Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology.
Synthesis in Journal of neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Awake craniotomy for brain tumor resection in the elderly: an institutional experience.Journal of neuro-oncology · 2026Article
- The mFI-11 frailty index as a predictor of surgical outcomes in elderly patients with brain metastases.Brain & spine · 2026Article
- Study on key markers of NETosis: predictive indicator for postoperative frailty following complete cytoreductive surgery in advanced ovarian cancer.Frontiers in immunology · 2026Article
- Predictors of prolonged length of stay in patients undergoing laser interstitial thermal therapy for intracranial tumors.Journal of neuro-oncology · 2025Article
- The prognostic role of frailty on outcomes following meningioma resection in the elderly: a matched analysis employing baseline functional status.Acta neurochirurgica · 2025Article
- Brain Metastases from Primary Cardiac Tumors: A Systematic Review of Diagnosis, Treatment, and Prognosis.Cancers · 2025Review
- Age is not a significant predictor of survival in patients with IDH-wildtype glioblastoma that undergo gross total resection and complete adjuvant chemoradiation.Frontiers in oncology · 2025Article
- Association of preoperative frailty with risk of postoperative delirium in older patients undergoing craniotomy: a prospective cohort study.BMC surgery · 2024Article
- Frailty indices predict mortality, complications and functional improvements in supratentorial meningioma patients over 80 years of age.Journal of neuro-oncology · 2024Article
- Strategies to Assess and Manage Frailty among Patients Diagnosed with Primary Malignant Brain Tumors.Current treatment options in oncology · 2024Review
- On the value of microsurgical resection compared to biopsy in elderly glioblastoma patients: A retrospective multicenter analysis and scoring system proposal.Neuro-oncology advancesArticle
- Prognostic Superiority of the White Cell-to-Lymphocyte Ratio (WLR) in Predicting Overall Survival in Patients With Gliomas.In vivo (Athens, Greece)Article
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Authors and funding
17 authors.
Funding
Abstract
purposeFrailty has gained prominence in neurosurgical oncology, with more studies exploring its relationship to postoperative outcomes in brain tumor patients. As this body of literature continues to grow, concisely reviewing recent developments in the field is necessary. Here we provide a systematic review of frailty in brain tumor patients subdivided by tumor type, incorporating both modern frailty indices and traditional Karnofsky Performance Status (KPS) metrics.
methodsSystematic literature review was performed using PRISMA guidelines. PubMed and Google Scholar were queried for articles related to frailty, KPS, and brain tumor outcomes. Only articles describing novel associations between frailty or KPS and primary intracranial tumors were included.
resultsAfter exclusion criteria, systematic review yielded 52 publications. Amongst malignant lesions, 16 studies focused on glioblastoma. Amongst benign tumors, 13 focused on meningiomas, and 6 focused on vestibular schwannomas. Seventeen studies grouped all brain tumor patients together. Seven studies incorporated both frailty indices and KPS into their analyses. Studies correlated frailty with various postoperative outcomes, including complications and mortality.
conclusionOur review identified several patterns of overall postsurgical outcomes reporting for patients with brain tumors and frailty. To date, reviews of frailty in patients with brain tumors have been largely limited to certain frailty indices, analyzing all patients together regardless of lesion etiology. Although this technique is beneficial in providing a general overview of frailty's use for brain tumor patients, given each tumor pathology has its own unique etiology, this combined approach potentially neglects key nuances governing frailty's use and prognostic value.
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