Evidence map›Paper›PMID 37624344›Full record

ArticleTropical medicine and infectious disease2023

Rectal Administration of

Ilaria Varotto-Boccazzi, Sara Epis, Giulia Maria Cattaneo, Noemi Guerrini, Alessandro Manenti, Diego Rubolini, Paolo Gabrieli, Domenico Otranto, Gianvincenzo Zuccotti, Emanuele Montomoli and 1 more

Open access · goldAbstract read
In one paragraph

Article in Tropical medicine and infectious disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Tropical medicine and infectious disease · 2026
    Article
  2. Article
  3. Frontiers in cellular and infection microbiology · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Subcutaneous, Oral, and Intranasal Immunization of BALB/c Mice withTropical medicine and infectious disease · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Ilaria Varotto-BoccazziDepartment of Biosciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-8008-0025
Sara EpisDepartment of Biosciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0001-8807-4802
Giulia Maria CattaneoDepartment of Biosciences, University of Milan, 20133 Milan, Italy.
Noemi GuerriniVisMederi, 53100 Siena, Italy.ORCID 0009-0001-8998-9446
Alessandro ManentiVisMederi, 53100 Siena, Italy.
Diego RuboliniDepartment of Environmental Science and Policy, University of Milan, 20133 Milan, Italy.ORCID 0000-0003-2703-5783
Paolo GabrieliDepartment of Biosciences, University of Milan, 20133 Milan, Italy.
Domenico OtrantoDepartment of Veterinary Medicine, University of Bari, 70010 Valenzano, Italy.ORCID 0000-0002-7518-476X
Gianvincenzo ZuccottiPediatric CRC 'Fondazione Romeo ed Enrica Invernizzi', University of Milan, 20157 Milan, Italy.ORCID 0000-0002-2795-9874
Emanuele MontomoliVisMederi, 53100 Siena, Italy.
Claudio BandiDepartment of Biosciences, University of Milan, 20133 Milan, Italy.
University of Milan · ITUniversity of Siena · ITBu-Ali Sina University · IRVisMederi Research · IT

Funding

Erogazione liberale per le attività di ricerca sul Coronavirus LIB_VT20_COVID_19_GZUCCOTTIErogazione liberale per le attività di ricerca sul Coronavirus LIB_VT20_COVID_19_SEPISFondazione Romeo ed Enrica Invernizzi LIB_VT21SEPISFondazione Romeo ed Enrica Invernizzi LIB_VT22CBAND
6 · The paper itself

Abstract

The mucosal immune system plays a pivotal role in the control of infections, as it represents the first line of defense against most pathogens, from respiratory viruses to intestinal parasites. Mucosal vaccination is thus regarded as a promising strategy to protect animals, including humans, from infections that are acquired by ingestion, inhalation or through the urogenital system. In addition, antigens delivered at the mucosal level can also elicit systemic immune responses. Therefore, mucosal vaccination is potentially effective also against systemic infections acquired through non-mucosal routes, for example, through the bite of hematophagous insects, as in the case of leishmaniasis, a widespread disease that affects humans and dogs. Here, we explored the potential of antigen rectal administration for the generation of anti-

Indexed as

canine leishmaniasisLeCoVax-2Leishmania vaccinemucosal immunitysera repurposingTh1/Th2 immune polarization

Identifiers

PMID37624344
PMCPMC10458511
OpenAlexW4385696869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.