Evidence map›Paper›PMID 37624115›Full record

ReviewTomography (Ann Arbor, Mich.)2023

The Role of Advanced MRI Sequences in the Diagnosis and Follow-Up of Adult Brainstem Gliomas: A Neuroradiological Review.

Alessia Guarnera, Andrea Romano, Giulia Moltoni, Tamara Ius, Serena Palizzi, Allegra Romano, Daniele Bagatto, Giuseppe Minniti, Alessandro Bozzao

Open access · goldAbstract readReview
In one paragraph

Review in Tomography (Ann Arbor, Mich.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Multidisciplinary consensus recommendations for the management of IDH-mutant grade 2 gliomas in Spain: a Delphi study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Alessia GuarneraNeuroradiology Unit, NESMOS Department Sant'Andrea Hospital, La Sapienza University of Rome, Via di Grottarossa, 1035-1039, 00189 Rome, Italy.ORCID 0000-0001-5529-7575
Andrea RomanoNeuroradiology Unit, NESMOS Department Sant'Andrea Hospital, La Sapienza University of Rome, Via di Grottarossa, 1035-1039, 00189 Rome, Italy.
Giulia MoltoniNeuroradiology Unit, NESMOS Department Sant'Andrea Hospital, La Sapienza University of Rome, Via di Grottarossa, 1035-1039, 00189 Rome, Italy.ORCID 0000-0003-0149-9918
Tamara IusNeurosurgery Unit, Head-Neck and NeuroScience Department, University Hospital of Udine, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy.ORCID 0000-0003-3741-0639
Serena PalizziNeuroradiology Unit, NESMOS Department Sant'Andrea Hospital, La Sapienza University of Rome, Via di Grottarossa, 1035-1039, 00189 Rome, Italy.
Allegra RomanoNeuroradiology Unit, NESMOS Department Sant'Andrea Hospital, La Sapienza University of Rome, Via di Grottarossa, 1035-1039, 00189 Rome, Italy.
Daniele BagattoNeuroradiology Unit, Department of Diagnostic Imaging, University Hospital of Udine, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy.
Giuseppe MinnitiDepartment of Radiological Sciences, Oncology and Anatomical Pathology, Division of Radiotherapy, La Sapienza University of Rome, 00161 Rome, Italy.
Alessandro BozzaoNeuroradiology Unit, NESMOS Department Sant'Andrea Hospital, La Sapienza University of Rome, Via di Grottarossa, 1035-1039, 00189 Rome, Italy.ORCID 0000-0002-8865-0723
Sapienza University of Rome · ITBambino Gesù Children's Hospital · ITIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 2021 WHO (World Health Organization) classification of brain tumors incorporated the rapid advances in the molecular, genetic, and pathogenesis understanding of brain tumor pathogenesis, behavior, and treatment response. It revolutionized brain tumor classification by placing great emphasis on molecular types and completely splitting adult-type and pediatric-type diffuse gliomas. Brainstem gliomas (BSGs) are the leading primary tumors of the brainstem, although they are quite uncommon in adults compared with the pediatric population, representing less than 2% of adult gliomas. Surgery is not always the treatment of choice since resection is rarely feasible and does not improve overall survival, and biopsies are not generally performed since the location is treacherous. Therefore, MRI (Magnetic Resonance Imaging) without and with gadolinium administration represents the optimal noninvasive radiological technique to suggest brainstem gliomas diagnosis, plan a multidisciplinary treatment and for follow-up evaluations. The MRI protocol encompasses morphological sequences as well as functional and advanced sequences, such as DWI/ADC (Diffusion-Weighted Imaging/Apparent Diffusion Coefficient), DTI (Diffusion Tensor Imaging), PWI (Perfusion-Weighted Imaging), and MRS (Magnetic Resonance Spectroscopy), which improve the accuracy of the diagnosis of BSGs by adding substantial information regarding the cellularity, the infiltrative behavior toward the v fiber tracts, the vascularity, and the molecular changes. Brainstem gliomas have been divided into four categories on the basis of their MRI radiological appearance, including diffuse intrinsic low-grade gliomas, enhancing malignant gliomas, localized tectal gliomas, and other forms. The aim of our review is to provide insight into the role of advanced MRI sequences in the diagnosis and follow-up of adult brainstem gliomas.

Indexed as

Brain Stem NeoplasmsGliomaAdultChildDiffusion Tensor ImagingFollow-Up StudiesHumansMagnetic Resonance Imaging2021 WHO classificationbrainstem gliomadiffuse intrinsic low-grade gliomasDTIDWIenhancing malignant gliomaslocalized tectal gliomasMRIMRSPWI

Identifiers

PMID37624115
PMCPMC10457939
OpenAlexW4385986949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.