Evidence map›Paper›PMID 37624102›Full record

ArticleInternational health2024

Concordance of emergency department physicians' decisions on HIV post-exposure prophylaxis with national guidelines: results from a retrospective cohort study.

Johannes Heck, Christoph Höner Zu Siederdissen, Olaf Krause, Sebastian Schröder, Martin Schulze Westhoff, Patrick-Pascal Strunz, Carsten Schumacher, Dirk O Stichtenoth, Jacobus J Bosch, Thorben Pape and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Johannes HeckHannover Medical School, Institute for Clinical Pharmacology, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.ORCID 0000-0002-5382-3014
Christoph Höner Zu SiederdissenHannover Medical School, Emergency Department, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.ORCID 0000-0002-8268-2345
Olaf KrauseHannover Medical School, Institute for General Practice and Palliative Care, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.ORCID 0000-0002-9932-1116
Sebastian SchröderHannover Medical School, Department of Psychiatry, Social Psychiatry and Psychotherapy, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.ORCID 0000-0003-0905-274X
Martin Schulze WesthoffHannover Medical School, Department of Psychiatry, Social Psychiatry and Psychotherapy, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.ORCID 0000-0003-3262-8137
Patrick-Pascal StrunzUniversity Hospital Würzburg, Department of Internal Medicine II, Rheumatology and Clinical Immunology, Oberdürrbacher Str. 6, 97080 Würzburg, Germany.ORCID 0000-0002-3168-7074
Carsten SchumacherHannover Medical School, Center for Clinical Trials, Feodor-Lynen-Str. 15, 30625 Hannover, Germany.ORCID 0000-0002-3012-4245
Dirk O StichtenothHannover Medical School, Institute for Clinical Pharmacology, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.ORCID 0000-0002-6526-0917
Jacobus J BoschCentre for Human Drug Research, Zernikedreef 8, 2333 CL Leiden, The Netherlands.ORCID 0000-0001-7653-885X
Thorben PapeHannover Medical School, Institute for Clinical Pharmacology, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.ORCID 0000-0003-1031-1913
Felix KoopHannover Medical School, Institute for Clinical Pharmacology, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.ORCID 0000-0001-7378-7877
Benjamin KrichevskyHannover Medical School, Institute for General Practice and Palliative Care, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.ORCID 0000-0001-5899-0113
Medizinische Hochschule Hannover · DELeiden University Medical Center · NLUniversitätsklinikum Würzburg · DE

Funding

Deutsche Forschungsgemeinschaft
6 · The paper itself

Abstract

backgroundPost-exposure prophylaxis (PEP) is an effective tool to prevent infection with HIV. Patients seeking PEP after potential HIV exposure usually present to the emergency department (ED). Our study sought to determine the concordance of ED physicians' decisions on HIV-PEP with national guidelines (primary objective) and to assess the clinical relevance of drug-drug interactions (DDIs) between the HIV-PEP regimen and patients' concomitant medication (secondary objective).

methodsWe conducted a retrospective cohort study at the ED of Hannover Medical School, Germany. Between 1 January 2018 and 31 December 2019, 113 of 11 246 screened patients presented to the ED after potential HIV exposure and were enrolled in the study.

resultsThe median age of the patients (82.3% male) was 30 y (IQR 25-35.5), 85.8% of potential HIV exposures were characterised as sexual and 85.0% presented within 72 h. ED physicians' decisions on HIV-PEP were concordant with national guidelines in 93.8%. No clinically relevant DDIs were detected.

conclusionsED physicians' decisions on HIV-PEP were highly concordant with national guidelines. Approximately 1% of patient presentations to the ED were related to HIV exposure; therefore, training ED physicians on HIV transmission risk assessment and indications/contraindications for HIV-PEP is paramount.

Indexed as

Anti-HIV AgentsHIV InfectionsPhysiciansEmergency Service, HospitalFemaleHumansMalePost-Exposure ProphylaxisRetrospective StudiesAnti-HIV Agentsdrug–drug interactionsdrug safetyemergency departmenthuman immunodeficiency virusinternal medicinepost-exposure prophylaxis

Identifiers

PMID37624102
PMCPMC10911529
OpenAlexW4386151688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.