ArticleAmerican journal of physiology. Heart and circulatory physiology2023
Three-dimensional mitochondria reconstructions of murine cardiac muscle changes in size across aging.
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Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 47 citations in OpenAlex.
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- Multiscale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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- The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Narrative review of mitochondrial dysfunction in aging-related salt-sensitive hypertension: outcomes, mechanisms, and therapeutic implications.Aging advances · 2025Article
- Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025Review
- The Role of Mitochondrial Dysfunction and Dynamics in Hypertensive Heart Disease: Mechanisms and Recent Advances.Biology · 2025Review
- Protocol for the Systematic Quantitative Ultrastructural Analysis of Mitochondria in Cardiac Tissue.Methods and protocols · 2025Article
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Authors and funding
40 authors at 15 institutions in 1 country.
Zer VueDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.
Kit NeikirkDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.
Larry VangDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.
Edgar Garza-LopezDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, United States.
Trace A ChristensenMicroscopy and Cell Analysis Core Facility, Mayo Clinic, Rochester, Minnesota, United States.
Jianqiang ShaoCentral Microscopy Research Facility, University of Iowa, Iowa City, Iowa, United States.
Jacob LamDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, United States.ORCID 0009-0003-3413-0612
Heather K BeasleyDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.ORCID 0000-0002-4636-2889
Andrea G MarshallDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.ORCID 0000-0001-9997-4478
Amber CrabtreeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.ORCID 0000-0003-1156-1658
Josephs AnudokemDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.ORCID 0000-0003-4002-0674
Benjamin RodriguezDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.
Benjamin KirkDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, United States.
Serif BacevacDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, United States.
Taylor BaronganDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.ORCID 0000-0001-8233-1986
Bryanna ShaoDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.
Dominique C StephensDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.
Kinuthia KabugiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.
Ho-Jin KohDepartment of Biological Sciences, Tennessee State University, Nashville, Tennessee, United States.
Alice KohDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.
Chantell S EvansDepartment of Cell Biology, Duke University School of Medicine, Durham, North Carolina, United States.ORCID 0000-0001-9401-8604
Brittany TaylorJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, United States.
Anilkumar K ReddyDepartment of Medicine, Baylor College of Medicine, Houston, Texas, United States.
Tyne Miller-FlemingDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Ky'Era V ActkinsDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Elma ZaganjorDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.
Nastaran DaneshgarDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-0703-0494
Sandra A MurrayDepartment of Cell Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-8267-9138
Bret C MobleyDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Steven M DamoDepartment of Life and Physical Sciences, Fisk University, Nashville, Tennessee, United States.
Jennifer A GaddyDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Blake RiggsDepartment of Biology at San Francisco State University, San Francisco, California, United States.
Celestine WanjallaDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0001-9159-5414
Annet KiraboDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0001-8580-9359
Melanie McReynoldsDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States.
Jose A GomezDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0001-8148-8308
Mark A PhillipsDepartment of Integrative Biology, Oregon State University, Corvallis, Oregon, United States.
Vernat ExilDivision of Cardiology, Department of Pediatrics, St. Louis University School of Medicine, St. Louis, Missouri, United States.
Dao-Fu DaiDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Antentor HintonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.ORCID 0000-0002-7730-952X
Vanderbilt University · USUniversity of Iowa · USVanderbilt University Medical Center · USBaylor College of Medicine · USDuke University · USFisk University · USJohns Hopkins University · USMayo Clinic in Florida · USOregon State University · USPennsylvania State University · USSan Francisco State University · USTennessee State University · USUniversity of Florida · USUniversity of Pittsburgh · USVA Tennessee Valley Healthcare System · US
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MTennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI APRIL PETTIT · 2015 to 2026
$27.5MMULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9MTraining In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1MPRIDE: Functional and Translational Genomics of Blood DisordersR25HL106365 · NHLBI · AUGUSTA UNIVERSITY · PI PACE, BETTY SUE · 2010 to 2024
$5.2MIntegrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
$3.9MUCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3MDetermining the contribution of zinc deficiency to perinatal Group B Streptococcus infectionsR01HD090061 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M, GADDY, JENNIFER A · 2017 to 2021
$2.5MUCSD Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) Faculty Development ProgramR25NS117367 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Victoria B Risbrough, Joann Trejo · 2020 to 2026
$1.6MInterinstitutional Program in Cell and Molecular Biology: A Graduate Training Path to Promote Traditional and Non-Traditional Professional OutcomesT32GM133353 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRODSKY, JEFFREY L., MURRAY, SANDRA ANN · 2020 to 2024
$1.5MBLRD VA I01 BX005352NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHLBI NIH HHS R25 HL106365NHLBI NIH HHS R25 HL145817NHLBI NIH HHS T32 HL007444NIAID NIH HHS P30 AI110527NICHD NIH HHS R01 HD090061NIDDK NIH HHS T32 DK007563NIDDK NIH HHS T32 DK101003NIGMS NIH HHS T32 GM133353NIH HHS 5R25HL106365-12NIH HHS DK007563NINDS NIH HHS R25 NS117367
Abstract
With sparse treatment options, cardiac disease remains a significant cause of death among humans. As a person ages, mitochondria breakdown and the heart becomes less efficient. Heart failure is linked to many mitochondria-associated processes, including endoplasmic reticulum stress, mitochondrial bioenergetics, insulin signaling, autophagy, and oxidative stress. The roles of key mitochondrial complexes that dictate the ultrastructure, such as the mitochondrial contact site and cristae organizing system (MICOS), in aging cardiac muscle are poorly understood. To better understand the cause of age-related alteration in mitochondrial structure in cardiac muscle, we used transmission electron microscopy (TEM) and serial block facing-scanning electron microscopy (SBF-SEM) to quantitatively analyze the three-dimensional (3-D) networks in cardiac muscle samples of male mice at aging intervals of 3 mo, 1 yr, and 2 yr. Here, we present the loss of cristae morphology, the inner folds of the mitochondria, across age. In conjunction with this, the three-dimensional (3-D) volume of mitochondria decreased. These findings mimicked observed phenotypes in murine cardiac fibroblasts with CRISPR/Cas9 knockout of
Indexed as
MitochondriaMyocardiumAgingAnimalsHeartHumansMaleMiceMitochondrial ProteinsSignal TransductionMitochondrial Proteinsagingcardiac muscle mitochondriaMICOSserial block-face SEMthree-dimensional morphometry
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