Evidence map›Paper›PMID 37624096›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

Dual effects of the small-conductance Ca

Nathaniel T Herrera, Xianwei Zhang, Haibo Ni, Mary M Maleckar, Jordi Heijman, Dobromir Dobrev, Eleonora Grandi, Stefano Morotti

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Restoration of mitochondrial CaJournal of molecular and cellular cardiology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. The KCa3.1 KCells · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Early Atrial Remodeling Drives Arrhythmia in Fabry Disease.Circulation. Arrhythmia and electrophysiology · 2025
    Article
  11. Exploring the mechanisms of sex-specific proarrhythmia in long QT syndrome through computational modeling.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 5 countries.

Nathaniel T HerreraDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0001-6063-6404
Xianwei ZhangDepartment of Pharmacology, University of California Davis, Davis, California, United States.
Haibo NiDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0003-0083-4286
Mary M MaleckarDepartment of Computational Physiology, Simula Research Laboratory, Oslo, Norway.
Jordi HeijmanDepartment of Cardiology, Faculty of Health, Medicine, and Life Sciences, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0002-1418-108X
Dobromir DobrevFaculty of Medicine, West German Heart and Vascular Center, Institute of Pharmacology, University Duisburg-Essen, Essen, Germany.
Eleonora GrandiDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0002-4401-8857
Stefano MorottiDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0001-8679-665X
University of California, Davis · USBaylor College of Medicine · USMaastricht University · NLSimula Research Laboratory · NO

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA · 2019 to 2026
$21.1M
Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Development of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7M
Sex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0M
Functional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac RemodelingR01HL141214 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Alexey V Glukhov · 2018 to 2026
$3.8M
Modeling of subcellular signaling crosstalk in failing myocytesR00HL138160 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MOROTTI, STEFANO · 2020 to 2022
$722k
NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R00 HL138160NHLBI NIH HHS R01 HL131517NHLBI NIH HHS R01 HL141214NHLBI NIH HHS T32 HL086350NIH HHS OT2 OD026580
6 · The paper itself

Abstract

By sensing changes in intracellular Ca

Indexed as

Atrial FibrillationAtrial RemodelingCardiac Conduction System DiseaseElectrophysiologyHeart AtriaHeart VentriclesHumansarrhythmiaatrial fibrillationatrial myocyte electrophysiologymathematical modelspontaneous Ca2+ release

Identifiers

PMID37624096
PMCPMC10659325
OpenAlexW4386153382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.