Evidence map›Paper›PMID 37623965›Full record

ReviewPathogens (Basel, Switzerland)2023

Mitochondrial Dysfunction in Bacterial Infections.

Nicholas M Maurice, Ruxana T Sadikot

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. EnterotoxigenicBiology · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nicholas M MauriceDepartment of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-8929-0483
Ruxana T SadikotVA Nebraska Western Iowa Health Care System, Omaha, NE 68105, USA.
Emory University · USVA Nebraska Western Iowa Health Care System · US

Funding

How HIV-related proteins increase the susceptibility to lung injury despite anti-retroviral therapyR01HL144478 · NHLBI · EMORY UNIVERSITY · PI GUIDOT, DAVID MARSHALL, SADIKOT, RUXANA T · 2019 to 2022
$1.6M
TREM-1 in Lung Immune ResponseI01BX001786 · VA · VETERANS HEALTH ADMINISTRATION · PI Ruxana T Sadikot · 2013 to 2026
–
Novel Therapies Targeting Mitochondrial Pathways in Lung Epithelial Response to S. Pneumoniae InfectionIK2BX005371 · VA · VETERANS HEALTH ADMINISTRATION · PI MAURICE, NICHOLAS MICHAEL · 2022 to 2025
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BLRD VA I01 BX001786BLRD VA IK2 BX005371NHLBI NIH HHS R01 HL144478NIH HHS R01 HL144478
6 · The paper itself

Abstract

Mitochondria are critical in numerous cellular processes, including energy generation. Bacterial pathogens target host cell mitochondria through various mechanisms to disturb the host response and improve bacterial survival. We review recent advances in the understanding of how bacteria cause mitochondrial dysfunction through perturbations in mitochondrial cell-death pathways, energy production, mitochondrial dynamics, mitochondrial quality control, DNA repair, and the mitochondrial unfolded protein response. We also briefly highlight possible therapeutic approaches aimed at restoring the host mitochondrial function as a novel strategy to enhance the host response to bacterial infection.

Indexed as

bacterial infectioninnate immunitymetabolismmitochondriamitochondrial dynamics

Identifiers

PMID37623965
PMCPMC10458073
OpenAlexW4385462186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.