Evidence map›Paper›PMID 37623950›Full record

ArticlePathogens (Basel, Switzerland)2023

Latent Tuberculosis Infection and Associated Risk Factors among People Living with HIV and HIV-Uninfected Individuals in Lithuania.

Elzbieta Matulyte, Zavinta Kancauskiene, Aidas Kausas, Jurgita Urboniene, Vilnele Lipnickiene, Jelena Kopeykiniene, Tomas Gudaitis, Sarunas Raudonis, Edvardas Danila, Dominique Costagliola and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Elzbieta MatulyteDepartment of Infectious Diseases and Dermatovenerology, Faculty of Medicine, Vilnius University Hospital Santaros Klinikos, Vilnius University, LT-08410 Vilnius, Lithuania.
Zavinta KancauskieneDepartment of Infectious Diseases, University Hospital of Klaipeda, LT-92888 Klaipeda, Lithuania.
Aidas KausasAdult Infectious Diseases Unit, Clinic of Conservative Medicine, Republican Siauliai County Hospital, LT-76231 Siauliai, Lithuania.
Jurgita UrbonieneCentre of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, LT-08410 Vilnius, Lithuania.
Vilnele LipnickieneNational Public Health Surveillance Laboratory, LT-10210 Vilnius, Lithuania.
Jelena KopeykinieneDepartment of Diagnostics, University Hospital of Klaipeda, LT-92888 Klaipeda, Lithuania.
Tomas GudaitisFaculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania.
Sarunas RaudonisFaculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania.
Edvardas DanilaFaculty of Medicine, Institute of Clinical Medicine, Clinic of Chest Diseases, Immunology, and Allergology, Vilnius University, LT-03101 Vilnius, Lithuania.
Dominique CostagliolaInstitut Pierre Louis Épidémiologie de Santé Publique, Sorbonne Université, INSERM, F75013 Paris, France.
Raimonda MatulionyteDepartment of Infectious Diseases and Dermatovenerology, Faculty of Medicine, Vilnius University Hospital Santaros Klinikos, Vilnius University, LT-08410 Vilnius, Lithuania.
Vilnius University · LTKlaipėda University · LTPublic institution Respublikinė Šiauliai Hospital · LTSorbonne Université · FR

Funding

The Western-Eastern European Partnership Initiative on HIV, Viral Hepatitis and TB (WEEPI, www.weepi.org) The project "Run-up to programmatic management of latent tuberculosis infection in HIV infected people in Lithuania", Project ID 482020
6 · The paper itself

Abstract

backgroundPeople living with HIV (PLHIV) with latent tuberculosis infection (LTBI) are at increased risk of tuberculosis (TB) reactivation compared to the HIV-negative population. Lithuania belongs to the 18 high-priority TB countries in the European region. The aim of this study was to compare the prevalence of LTBI and LTBI-related risk factors between PLHIV and HIV-uninfected populations.

methodsA cross-sectional study was conducted in three Lithuanian Infectious Diseases centres from August 2018 to May 2022 using the interferon gamma release assay (IGRA) and tuberculin skin test (TST) in Vilnius, and IGRA only in Siauliai and Klaipeda. Cohen's kappa was used to assess IGRA and TST agreement. A structured questionnaire was completed by the study participants. LTBI-related risk factors were identified using a multivariable logistic regression model.

resultsIn total, 391 PLHIV and 443 HIV-uninfected individuals enrolled, with a median age of 41 (IQR 36-48) and 43 (IQR 36-50), consisting of 69.8% and 65.5% male, respectively. The prevalence of LTBI defined by positive IGRA and/or TST among PLHIV was higher compared to that in the HIV-uninfected population (20.5% vs. 15.3%; OR 1.42; 95% CI 1.02-2.03;

conclusionsThe prevalence of LTBI among PLHIV in Lithuania is higher compared to that in the HIV-uninfected population and the European average. The association with IDU in PLHIV emphasizes the need for integrated HIV, TB and substance abuse treatment to provide patient-centred care.

Indexed as

HIVLTBIprevalencerisk factorsTB

Identifiers

PMID37623950
PMCPMC10459141
OpenAlexW4385342192

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.