Evidence map›Paper›PMID 37623873›Full record

ArticleMetabolites2023

Effect of Noise and Music on Neurotransmitters in the Amygdala: The Role Auditory Stimuli Play in Emotion Regulation.

Haoyang Nian, Susu Ding, Yanru Feng, Honggui Liu, Jianhong Li, Xiang Li, Runxiang Zhang, Jun Bao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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  2. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Haoyang NianCollege of Animal Science and Technology, Northeast Agricultural University, Mucai Street No. 59, Harbin 150030, China.
Susu DingCollege of Animal Science and Technology, Northeast Agricultural University, Mucai Street No. 59, Harbin 150030, China.
Yanru FengCollege of Animal Science and Technology, Northeast Agricultural University, Mucai Street No. 59, Harbin 150030, China.
Honggui LiuCollege of Animal Science and Technology, Northeast Agricultural University, Mucai Street No. 59, Harbin 150030, China.
Jianhong LiCollege of Life Science, Northeast Agricultural University, Mucai Street No. 59, Harbin 150030, China.ORCID 0000-0002-7736-0333
Xiang LiCollege of Animal Science and Technology, Northeast Agricultural University, Mucai Street No. 59, Harbin 150030, China.ORCID 0000-0001-8944-086X
Runxiang ZhangCollege of Animal Science and Technology, Northeast Agricultural University, Mucai Street No. 59, Harbin 150030, China.ORCID 0000-0002-6315-9399
Jun BaoCollege of Animal Science and Technology, Northeast Agricultural University, Mucai Street No. 59, Harbin 150030, China.ORCID 0000-0002-9492-0507
Northeast Agricultural University · CN

Funding

National Natural Science Foundation of China No.31972606National Natural Science Foundation of China No.32172788
6 · The paper itself

Abstract

Stress caused by noise is becoming widespread globally. Noise may lead to deafness, endocrine disorders, neurological diseases, and a decline in mental health. The mechanism behind noise-induced neurodevelopmental abnormalities is unclear, but apoptosis and pro-inflammatory signals may play an important role. In this study, weaned piglets were used as a model to explore noise-induced neurodevelopmental abnormalities. We hypothesized that long-term noise exposure would induce anxiety and cause acute stress, exhibited by alterations in neurotransmission in the amygdala. A total of 72 hybrid piglets (Large White × Duroc × Min Pig) were randomly divided into three groups, including noise (exposed to mechanical noise, 80-85 dB), control (blank, exposed to natural background sound, <40 dB), and music (positive control, exposed to Mozart K.448, 60-70 dB) groups. The piglets were exposed to 6 h of auditory noise daily (10:00-16:00) for 28 days. Compared with the control group, piglets exposed to noise showed more aggressive behavior. The expression of Caspase3, Caspase9, Bax, NF-κB (p56), TLR4, MYD88, I κ B α, IL-1 β, TNF-α, and IL-12RB2 was significantly upregulated in the amygdala, while the expression of Nrf2, HO-1, CAT, and SOD was downregulated in piglets in the noise group. Cell death occurred, and numerous inflammatory cells accumulated in the amygdala of piglets in the noise group. Targeted metabolomics showed that the content of inhibitory neurotransmitter GABA was higher in the amygdala of piglets in the noise group. Compared with the noise group, piglets in the music group displayed more positive emotion-related behaviors. Compared with the noise group, the expression of genes related to apoptosis, inflammation, and oxidative damage was lower in the music group. Cells of the amygdala in the music group were also of normal morphology. Our results show that noise-induced stress causes apoptosis and neuroinflammation in the amygdala and induces anxiety during the early neonatal neural development of piglets. In contrast, to some extent, music alleviates noise-induced anxiety.

Indexed as

amygdalaGABAmetabolomicsneuroinflammationnoisepiglets

Identifiers

PMID37623873
PMCPMC10456833
OpenAlexW4385654801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.