Evidence map›Paper›PMID 37623845›Full record

ArticleMetabolites2023

Investigating the Acute Metabolic Effects of the N-Methyl Carbamate Insecticide, Methomyl, on Mouse Liver.

Amy M Groswald, Tyler C Gripshover, Walter H Watson, Banrida Wahlang, Jianzhu Luo, Loretta L Jophlin, Matthew C Cave

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Amy M GroswaldDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Tyler C GripshoverDepartment of Pharmacology & Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Walter H WatsonDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Banrida WahlangDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Jianzhu LuoDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Loretta L JophlinDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Matthew C CaveDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
University of Louisville · US

Funding

Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2016 to 2025
$24.1M
Superfund Training CoreP42ES023716 · NIEHS · UNIVERSITY OF LOUISVILLE · PI HEIN, DAVID W · 2017 to 2025
$18.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9M
University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0M
UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAMT32ES011564 · NIEHS · UNIVERSITY OF LOUISVILLE · PI David W Hein, John Pierce Wise · 2004 to 2026
$7.1M
Environmental Liver DiseaseR35ES028373 · NIEHS · UNIVERSITY OF LOUISVILLE · PI CAVE, MATTHEW C · 2017 to 2024
$4.0M
Exposome and Precision Medicine in NAFLDR01ES032189 · NIEHS · UNIVERSITY OF LOUISVILLE · PI CAVE, MATTHEW C · 2020 to 2022
$1.9M
Summer Environmental Health Sciences Training ProgramT35ES014559 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Matthew C Cave, Daniel Joseph Conklin · 2006 to 2026
$751k
Interaction of the Microtubule Cytoskeleton and Perilipin-2 Regulates Hepatic Lipid Droplets - a Potential Therapeutic Target for Fatty Liver DiseaseK08DK123381 · NIDDK · UNIVERSITY OF LOUISVILLE · PI JOPHLIN, LORETTA L. · 2021 to 2023
$497k
Evaluating mechanisms of sex differences in environmentally-induced metabolic diseasesK01ES033289 · NIEHS · UNIVERSITY OF LOUISVILLE · PI WAHLANG, BANRIDA · 2022 to 2024
$448k
NIAAA NIH HHS P50 AA024337NIAAA NIH HHS P50AA024337NIDDK NIH HHS K08 DK123381NIDDK NIH HHS K08DK123381NIEHS NIH HHS K01 ES033289NIEHS NIH HHS K01ES033289NIEHS NIH HHS P30 ES030283NIEHS NIH HHS P30ES030283NIEHS NIH HHS P42 ES023716NIEHS NIH HHS P42ES023716NIEHS NIH HHS R01 ES032189NIEHS NIH HHS R01ES032189NIEHS NIH HHS R35 ES028373NIEHS NIH HHS R35ES028373NIEHS NIH HHS T32 ES011564NIEHS NIH HHS T32ES011564NIEHS NIH HHS T35 ES014559NIEHS NIH HHS T35ES014559NIGMS NIH HHS P20 GM113226NIGMS NIH HHS P20GM113226
6 · The paper itself

Abstract

Many pesticides have been identified as endocrine and metabolism-disrupting chemicals with hepatotoxic effects. However, data are limited for insecticides in the n-methyl carbamate class, including methomyl. Here, we investigate the liver and systemic metabolic effects of methomyl in a mouse model. We hypothesize that methomyl exposure will disrupt xenobiotic and intermediary metabolism and promote hepatic steatosis in mice. Male C57BL/6 mice were exposed daily to 0-5 mg/kg methomyl for 18 days. Mice were fed water and regular chow diet ad libitum. Metabolic phenotyping was performed, and tissue samples were collected. Effects were generally greatest at the highest methomyl dose, which induced

Indexed as

endocrine disruptorenvironmental liver diseasemetabolic disrupting chemicalpesticidetoxicant-associated steatohepatitistoxicant-associated steatotic liver disease

Identifiers

PMID37623845
PMCPMC10456691
OpenAlexW4385445253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.