Evidence map›Paper›PMID 37623713›Full record

ArticleMarine drugs2023

Evaluation of Toxicity Equivalency Factors of Tetrodotoxin Analogues with a Neuro-2a Cell-Based Assay and Application to Puffer Fish from Greece.

Mounira Alkassar, Andres Sanchez-Henao, Jaume Reverté, Lourdes Barreiro, Maria Rambla-Alegre, Sandra Leonardo, Manolis Mandalakis, Panagiota Peristeraki, Jorge Diogène, Mònica Campàs

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  4. Chemical properties and biological activities of three highly purified major tetrodotoxin analogues.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mounira AlkassarInstitut de Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou km 5.5, 43540 La Ràpita, Spain.ORCID 0000-0003-4320-7020
Andres Sanchez-HenaoInstitut de Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou km 5.5, 43540 La Ràpita, Spain.
Jaume RevertéInstitut de Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou km 5.5, 43540 La Ràpita, Spain.ORCID 0009-0002-6914-2851
Lourdes BarreiroInstitut de Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou km 5.5, 43540 La Ràpita, Spain.
Maria Rambla-AlegreInstitut de Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou km 5.5, 43540 La Ràpita, Spain.ORCID 0000-0003-4276-276X
Sandra LeonardoInstitut de Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou km 5.5, 43540 La Ràpita, Spain.
Manolis MandalakisInstitute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research, 71003 Heraklion, Greece.ORCID 0000-0002-7469-4290
Panagiota PeristerakiInstitute of Marine Biological Resources and Inland Waters, Hellenic Centre for Marine Research, 71003 Heraklion, Greece.
Jorge DiogèneInstitut de Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou km 5.5, 43540 La Ràpita, Spain.ORCID 0000-0002-6567-6891
Mònica CampàsInstitut de Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou km 5.5, 43540 La Ràpita, Spain.ORCID 0000-0002-1220-7100
Institute of Agrifood Research and Technology · ESHellenic Centre for Marine Research · GR

Funding

Agencia Estatal de Investigación, España PID2020-112976RB-C21Agencia Estatal de Investigación, España PRE2019-088181Canary Islands Research Agency, España APCR2022010011IRTA CPI0422IRTA and URV 2020PMF-PIPF-07
6 · The paper itself

Abstract

Tetrodotoxin (TTX) is a potent marine neurotoxin involved in poisoning cases, especially through the consumption of puffer fish. Knowledge of the toxicity equivalency factors (TEFs) of TTX analogues is crucial in monitoring programs to estimate the toxicity of samples analyzed with instrumental analysis methods. In this work, TTX analogues were isolated from the liver of a

Indexed as

TetraodontiformesAnimalsChromatography, LiquidGreeceTandem Mass SpectrometryTetrodotoxinTetrodotoxincell-based assay (CBA)Lagocephalus sceleratusliquid chromatography-tandem mass spectrometry (LC-MS/MS)puffer fishtetrodotoxin (TTX)toxicity equivalency factor (TEF)TTX analogue

Identifiers

PMID37623713
PMCPMC10455759
OpenAlexW4385423156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.