Evidence map›Paper›PMID 37623679›Full record

ArticleJournal of functional biomaterials2023

Effect of the Correction of Bilateral Differences in Masseter Muscle Functional Pressure on the Mandible of Growing Rats.

Shuhei Mizuno, Satoru Matsunaga, Norio Kasahara, Masaaki Kasahara, Yoshiaki Shimoo, Shinichi Abe, Takayoshi Nakano, Takuya Ishimoto, Atsuhiko Hikita, Kunihiko Nojima and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Shuhei MizunoOral Health Science Center, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-006, Japan.
Satoru MatsunagaOral Health Science Center, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-006, Japan.ORCID 0000-0001-7059-8413
Norio KasaharaOral Health Science Center, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-006, Japan.ORCID 0000-0002-5748-2042
Masaaki KasaharaOral Health Science Center, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-006, Japan.
Yoshiaki ShimooMalo Dental and Medical Tokyo, 7-8-10, Chuo-ku, Ginza, Tokyo 104-0061, Japan.
Shinichi AbeOral Health Science Center, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-006, Japan.ORCID 0000-0003-4632-9736
Takayoshi NakanoDivision of Materials & Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita 565-0871, Japan.ORCID 0000-0001-8052-1698
Takuya IshimotoAluminium Research Center, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan.
Atsuhiko HikitaDepartment of Tissue Engineering, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan.
Kunihiko NojimaOral Health Science Center, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-006, Japan.ORCID 0009-0000-6440-2752
Yasushi NishiiOral Health Science Center, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-006, Japan.ORCID 0000-0001-7695-1564
Tokyo Dental College · JPThe University of Osaka · JPUniversity of Tokyo Hospital · JPUniversity of Toyama · JP

Funding

Private University Research Branding Project from MEXT of Japan 18K09643Private University Research Branding Project from MEXT of Japan 21K09961
6 · The paper itself

Abstract

The objective of this study is to clarify the effect of restoring the lowered masticatory muscle functional pressure and correcting bilateral differences in masticatory muscle functional pressure on jawbone growth during growth and development with a quantitative evaluation of the changes in the micro/nanostructural characteristics of entheses. Male Wistar rats aged 4 weeks were divided into an experimental group injected with a botulinum toxin serotype A (BoNT/A) formulation to reduce muscle function (BTX group) and a control group (CTRL group). They were euthanised after 6, 8, 10, 12, and 16 weeks after measuring the difference between the midline of the upper and lower incisors. The mandibles were harvested for histological examination, second harmonic generation imaging, and the quantitative evaluation of biological apatite (BAp) crystal alignment. The midline difference decreased with age in weeks. In rats from 6 weeks after BoNT/A administration to 12 weeks after administration, the collagen fibre bundle diameter was significantly smaller in the BTX group; the difference between the two groups decreased with increasing age. BAp crystal alignment was significantly different on the

Indexed as

biological apatite crystallitebone qualitycollagen fibremicrobeam X-ray diffractionsecond harmonic generation imaging

Identifiers

PMID37623679
PMCPMC10455519
OpenAlexW4386049684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.