Trial reportInternational journal of environmental research and public health2023
The Betel Nut Intervention Trial (BENIT)-A Randomized Clinical Trial for Areca Nut and Betel Quid Cessation: Primary Outcomes.
Trial report in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02942745 (NIH-NCI U54 University of Guam/Cancer Center of Hawaii Partnership Full Project II), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NIH-NCI U54 University of Guam/Cancer Center of Hawaii Partnership Full Project II: The Betel Nut Intervention Trial
Who cites it
8 citing papers in PubMed.
- Efficiency of behaviour support interventions for smokeless tobacco cessation by dentists.Substance abuse treatment, prevention, and policy · 2026Trial
- Understanding betel nut addiction: a review of harmful consequences, underlying neurobiology, and emerging intervention strategies.Translational psychiatry · 2026Review
- Cultural carcinogens in oral squamous cell carcinoma risk across global populations.Oncoscience · 2026Review
- Periodontitis presenting among betel quid users: A case series.Clinical advances in periodontics · 2025Article
- Association Between Betel Nut Chewing and Body Mass Index: A Cross-Sectional Study in Guam.International journal of environmental research and public health · 2025Article
- Arecoline Induces ROS Accumulation, Transcription of Proinflammatory Factors, and Expression of KRT6 in Oral Epithelial Cells.Biomedicines · 2024Article
- Facilitator experiences and lessons learned from the Betel nut intervention trial (BENIT).BMC public health · 2024Article
- What Motivates Betel Quid Chewers to Quit? An Analysis of Several Cessation-Relevant Variables.Substance use & misuse · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundAreca nut and betel quid (ANBQ) chewing is a widespread carcinogenic habit. The BENIT (ClinicalTrials-NCT02942745) is the first known randomized trial designed for ANBQ chewers.
methodsWe compared the intensive behavioral treatment intervention condition (IC) with the control condition (CC) in the BENIT and included a 5-stage early stopping rule. We report the primary analysis at stage 3. English-literate adults in Guam and Saipan who self-identified as ANBQ chewers with tobacco were enrolled between August 2016 and August 2020. IC participants (
resultsCessation rates were 38.6% (IC) and 9.1% (CC). Proportional hazards regression revealed a
conclusionsRobust self-reported intervention effects at day 22 suggest that intensive cessation programs such as BENIT should be further developed and implemented on a larger scale.
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Registered trials
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