Evidence map›Paper›PMID 37623098›Full record

ReviewGels (Basel, Switzerland)2023

Collagen-Based Hydrogels for the Eye: A Comprehensive Review.

Dhwani Rana, Nimeet Desai, Sagar Salave, Bharathi Karunakaran, Jyotsnendu Giri, Derajram Benival, Srividya Gorantla, Nagavendra Kommineni

Open access · goldAbstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Dhwani RanaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, Gujarat, India.ORCID 0000-0002-1591-9226
Nimeet DesaiDepartment of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, Telangana, India.ORCID 0000-0002-3575-6671
Sagar SalaveNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, Gujarat, India.ORCID 0000-0003-3000-1998
Bharathi KarunakaranNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, Gujarat, India.
Jyotsnendu GiriDepartment of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, Telangana, India.
Derajram BenivalNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, Gujarat, India.
Srividya GorantlaDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
Nagavendra KommineniCenter for Biomedical Research, Population Council, New York, NY 10065, USA.ORCID 0000-0003-4771-7925
National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad · INIndian Institute of Technology Hyderabad · INPopulation Council · USTufts University · US

Funding

Department of Science and Technology, the Ministry of Science and Technology, the Science and Engineering Board, India DST/IMP/2018/000687
6 · The paper itself

Abstract

Collagen-based hydrogels have emerged as a highly promising platform for diverse applications in ophthalmology, spanning from drug delivery systems to biomedical interventions. This review explores the diverse sources of collagen, which give rise to different types of collagen protein. The critical isolation and purification steps are discussed, emphasizing their pivotal role in preparing collagen for biomedical use. To ensure collagen quality and purity, and the suitability of collagen for targeted applications, a comprehensive characterization and quality control are essential, encompassing assessments of its physical, chemical, and biological properties. Also, various cross-linking collagen methods have been examined for providing insight into this crucial process. This comprehensive review delves into every facet of collagen and explores the wide-ranging applications of collagen-based hydrogels, with a particular emphasis on their use in drug delivery systems and their potential in diverse biomedical interventions. By consolidating current knowledge and advancements in the field, this review aims to provide a detailed overview of the utilization of engineered collagen-based hydrogels in ocular therapeutics.

Indexed as

biomedical applicationscollagendrug deliveryeyehydrogel

Identifiers

PMID37623098
PMCPMC10454301
OpenAlexW4385708880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.