ReviewBiomimetics (Basel, Switzerland)2023
Improving Oral Health with Fluoride-Free Calcium-Phosphate-Based Biomimetic Toothpastes: An Update of the Clinical Evidence.
Review in Biomimetics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Hydroxyapatite-Fluoride Toothpastes on Caries Activity: A Triple-Blind Randomized Clinical Trial.International dental journal · 2025Trial
- Tooth Color Change Following Bleaching with a Desensitizing Double-Layer Technique.Bioengineering (Basel, Switzerland) · 2026Article
- Efficacy of calcium hypophosphite toothpaste in remineralizing initial caries in vitro.BMC oral health · 2026Article
- In vitro study on the neutralization potential of particulate hydroxyapatite in erosive acids.BDJ open · 2026Article
- Dental Erosion Management: From Remineralization to Emerging Regenerative Approaches-A Narrative Review.Biomimetics (Basel, Switzerland) · 2026Review
- Fluoride-Free Toothpastes for Caries Prevention: A Systematic Review of Clinical Evidence on Active Ingredients.Clinical, cosmetic and investigational dentistry · 2026Review
- Bleaching efficacy and enamel effects of tricalcium phosphate dentifrices containing charcoal or hydrogen peroxide.Brazilian dental journal · 2026Article
- New NaBMC chemistry · 2025Article
- Evaluation of preventive methods used to interrupt the progression of early caries lesions.Journal of clinical and experimental dentistry · 2025Review
- Comparative evaluation of Turkish dentists' knowledge, attitudes, and practices in caries management according to specialty education.BMC medical education · 2025Article
- Surface Analysis of Lithium Disilicate Ceramics After Use of Charcoal-Containing Toothpastes.Journal of functional biomaterials · 2025Article
- Home-use Photobiomodulation for Pain Management and Recovery after Lower Third Molar Extraction: A Pilot Split-Mouth Study.Journal of lasers in medical sciences · 2025Article
- Nano-Hydroxyapatite toothpaste of rice field snail shell combined with basil leaf extract as a remineralizing and antibacterial agent to prevent dental caries.Journal of clinical and experimental dentistry · 2024Article
- The Remineralization of Enamel from Saliva: A Chemical Perspective.Dentistry journal · 2024Review
- Caries Etiology and Preventive Measures.European journal of dentistry · 2024Article
- Case Report on Caries Assessment Using Intraoral Scanner Compared with Bitewing Radiographs.European journal of dentistry · 2024Article
- Prevention of Dental Caries: A Review on the Improvements of Toothpaste Formulations from 1900 to 2023.Dentistry journal · 2024Review
- Doses of fluoride toothpaste for children up to 24 months.BDJ open · 2024Article
- Salivary alpha-amylase activity and its association with early childhood caries and rampant caries experience: a cross-sectional study.Frontiers in medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the demand for clinically effective fluoride-free oral care products for consumers increases, it is important to document which types of toothpastes have been shown in clinical studies to be effective in improving oral health. In this review, we included different indications, i.e., caries prevention, improving periodontal health, reducing dentin hypersensitivity, protecting against dental erosion, and safely improving tooth whitening in defining what constitutes improvement in oral health. While there are several professional and consumer fluoride-containing formulations fortified with calcium-phosphate-based ingredients, this review focuses on fluoride-free toothpastes containing biomimetic calcium-phosphate-based molecules as the primary active ingredients. Several databases were searched, and only clinical trials in human subjects were included; in vitro and animal studies were excluded. There were 62 oral health clinical trials on biomimetic hydroxyapatite (HAP), 57 on casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), 26 on calcium sodium phosphosilicate (CSPS, or so called Bioglass), and 2 on β-tricalcium phosphate (β-TCP). HAP formulations were tested the most in clinical trials for benefits in preventing caries, dentin hypersensitivity, improving periodontal health, and tooth whitening. Based on the current clinical evidence to date, fluoride-free HAP toothpaste formulations are the most versatile of the calcium phosphate active ingredients in toothpastes for improving oral health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.