ArticleCNS neuroscience & therapeutics2024
Abnormal white matter structural network topological property in patients with temporal lobe epilepsy.
Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Cognitive impairment and associated white matter organization abnormalities across the illness course of schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Aberrant Functional Lateralization and Interhemispheric Synergy in High Myopia: Insights From Neurotransmitter Distribution Signatures and Machine Learning Classification.Investigative ophthalmology & visual science · 2026Article
- Altered white matter structural network in self-limited epilepsy with centrotemporal spikes.Quantitative imaging in medicine and surgery · 2026Article
- MRI-based brain structural changes in adult-onset dentatorubral-pallidoluysian atrophy.Neuroradiology · 2025Article
- Abnormal Alterations of the White Matter Structural Network in Patients with Herpes Zoster and Postherpetic Neuralgia.Brain topography · 2025Article
- Brain imaging traits and epilepsy: Unraveling causal links via mendelian randomization.Brain and behavior · 2024Article
- Edge-wise analysis reveals white matter connectivity associated with focal to bilateral tonic-clonic seizures.Epilepsia · 2024Article
- Topological regularization of networks in temporal lobe epilepsy: a structural MRI study.Frontiers in neuroscience · 2024Article
- Abnormal white matter structural network topological property in patients with temporal lobe epilepsy.CNS neuroscience & therapeutics · 2024Article
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6 authors.
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Abstract
backgroundDiffusion tensor imaging (DTI) studies have demonstrated white matter (WM) abnormalities in patients with temporal lobe epilepsy (TLE). However, alterations in the topological properties of the WM structural network in patients with TLE remain unclear. Graph theoretical analysis provides a new perspective for evaluating the connectivity of WM structural networks.
methodsDTI was used to map the structural networks of 18 patients with TLE (10 males and 8 females) and 29 (17 males and 12 females) age- and gender-matched normal controls (NC). Graph theory was used to analyze the whole-brain networks and their topological properties between the two groups. Finally, partial correlation analyses were performed on the weighted network properties and clinical characteristics, namely, duration of epilepsy, verbal intelligence quotient (IQ), and performance IQ.
resultsPatients with TLE exhibited reduced global efficiency and increased characteristic path length. A total of 31 regions with nodal efficiency alterations were detected in the fractional anisotropy_ weighted network of the patients. Communication hubs, such as the middle temporal gyrus, right inferior temporal gyrus, left calcarine, and right superior parietal gyrus, were also differently distributed in the patients compared with the NC. Several node regions showed close relationships with duration of epilepsy, verbal IQ, and performance IQ.
conclusionsOur results demonstrate the disruption of the WM structural network in TLE patients. This study may contribute to the further understanding of the pathological mechanism of TLE.
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