Evidence map›Paper›PMID 37622003›Full record

ArticleiScience2023

Estrogen receptor alpha regulates uterine epithelial lineage specification and homeostasis.

Jason A Rizo, Kimberly M Davenport, Wipawee Winuthayanon, Thomas E Spencer, Andrew M Kelleher

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Unveiling estrogen's role: a comprehensive review of its impact on skin health and disease.Apoptosis : an international journal on programmed cell death · 2026
    Review
  7. TGFBR2 coordinates the endometrial response to estrogen, regulating endometrial hyperplasia and fertility.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Retinoic acid antagonizes estrogen signaling to maintain adult uterine cell fate.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Uterine organoids reveal insights into epithelial specification and plasticity in development and disease.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Decoding Müllerian Duct Epithelial Regionalization.Molecular reproduction and development · 2025
    Review
  14. Article
  15. Single-cell insights into epithelial morphogenesis in the neonatal mouse uterus.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Chitosan/Alginate-LoadedReproductive medicine and biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jason A RizoDivision of Animal Sciences, University of Missouri, Columbia, MO 65211, USA.
Kimberly M DavenportDivision of Animal Sciences, University of Missouri, Columbia, MO 65211, USA.
Wipawee WinuthayanonDepartment of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, MO 65211, USA.
Thomas E SpencerDivision of Animal Sciences, University of Missouri, Columbia, MO 65211, USA.
Andrew M KelleherDepartment of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, MO 65211, USA.
University of Missouri Health System · USUniversity of Missouri · US

Funding

Mechanisms Governing Uterine Epithelial PlasticityR01HD112315 · NICHD · UNIVERSITY OF MISSOURI-COLUMBIA · PI Andrew M Kelleher · 2023 to 2026
$1.7M
The actions of steroid hormones on oviduct functionR01HD097087 · NICHD · WASHINGTON STATE UNIVERSITY · PI WINUTHAYANON, WIPAWEE · 2019 to 2023
$1.7M
Biological Role of Uterine Glands in PregnancyR01HD096266 · NICHD · UNIVERSITY OF MISSOURI-COLUMBIA · PI SPENCER, THOMAS E · 2018 to 2022
$1.6M
NICHD NIH HHS R01 HD096266NICHD NIH HHS R01 HD097087NICHD NIH HHS R01 HD112315
6 · The paper itself

Abstract

Postnatal development of the uterus involves specification of undifferentiated epithelium into uterine-type epithelium. That specification is regulated by stromal-epithelial interactions as well as intrinsic cell-specific transcription factors and gene regulatory networks. This study utilized mouse genetic models of

Indexed as

Cell biologyDevelopmental biologyMolecular biologyOmicsTranscriptomics

Identifiers

PMID37622003
PMCPMC10445454
OpenAlexW4385704152

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.