Evidence map›Paper›PMID 37621853›Full record

ArticleJournal of dermatology and skin science2022

Effects of Obesity on Infections with Emphasis on Skin Infections and Wound Healing.

Daniela Frasca, Natasa Strbo

Open access · hybridAbstract read
In one paragraph

Article in Journal of dermatology and skin science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Polysaccharide based biomaterials for advanced wound healing applications.Frontiers in cellular and infection microbiology · 2026
    Review
  9. Article
  10. Microbial Biotransformation of Chicory byInternational journal of molecular sciences · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Defective lymphatic vasculature in obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Daniela FrascaDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL USA.
Natasa StrboDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL USA.
Sylvester Comprehensive Cancer Center · USUniversity of Miami · US

Funding

Perforin-2: The role of a novel antimicrobial protein in diabetic foot ulcersR01NR015649 · NINR · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI STRBO, NATASA, TOMIC-CANIC, MARJANA · 2015 to 2019
$2.6M
How do obesity and related inflammation decrease antibody responses in aging?R01AG023717 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BLOMBERG, BONNIE B., FRASCA, DANIELA · 2017 to 2021
$1.8M
Obesity accelerates age defects in human B cells and induces autoimmunityR56AG059719 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FRASCA, DANIELA · 2018 to 2018
$384k
NIA NIH HHS R01 AG023717NIA NIH HHS R56 AG059719NINR NIH HHS R01 NR015649
6 · The paper itself

Abstract

Obesity represents a serious health problem as it is rapidly increasing worldwide. Obesity is associated with reduced health span and life span, decreased responses to infections and vaccination and increased frequency of inflammatory conditions. In this review, we summarize published data showing that obesity increases the risk of different types of infections, with a special focus on skin infections. Obesity also induces skin changes and conditions (inflammation-based and hypertrophic) which are often associated with fungi or bacteria overgrowth. The association of obesity with the skin microbiome has been established in both mice and humans. Balance of commensal microbes controls skin homeostasis and the host immune response, while changes in normal physiologic skin microbiome composition and pathologic bacteria contribute to skin diseases. We also summarize the major steps in wound healing and how obesity affects each of them. The role that immune cells have in this process is also described. Although the studies summarized in this review clearly demonstrate the deleterious effects of obesity on wound healing, additional studies are needed to better characterize the cellular and molecular mechanisms involved and identify specific targets of intervention.

Indexed as

InfectionsObesityWound healing

Identifiers

PMID37621853
PMCPMC10448872
OpenAlexW4292714570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.